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Genome-wide analysis of circular RNAs in Goat skin fibroblast cells (GSF cells) in response to Orf virus infection

ABSTRACT: Genome-wide analysis of circular RNAs in Goat skin fibroblast cells (GSF cells) in response to Orf virus infection

PROVIDER: PRJNA498267 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8102381_1.fastq.gz	Fastqsanger.gz
	SRR8102381_2.fastq.gz	Fastqsanger.gz
	SRR8102383_1.fastq.gz	Fastqsanger.gz
	SRR8102383_2.fastq.gz	Fastqsanger.gz
	SRR8102384_1.fastq.gz	Fastqsanger.gz

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Genome-wide analysis of circular RNAs in Goat skin fibroblast cells (GSF cells) in response to Orf virus infection

Project description:To find out differently expressed circRNAs during Orf virus infection of GSF cells and their potential roles in response to ORFV infection

2018-10-25 | GSE121725 | GEO

Alterations of miRNAs in Goat skin fibroblast cells (GSF cells) in response to Orf virus infection

Project description:To find out differently expressed miRNAs in GSF cells in response to Orf virus infection and to construct circRNA-miRNA networks

2018-10-25 | GSE121726 | GEO

Alterations of miRNAs in Goat skin fibroblast cells (GSF cells) in response to Orf virus infection

Project description:Alterations of miRNAs in Goat skin fibroblast cells (GSF cells) in response to Orf virus infection

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Differentially expressed mRNAs in GSF cells infected by Orf virus at 18h.p.i (OV18h.p.i) and 30h.p.i (OV30h.p.i) compared with the mock-infected GSF cells [mRNA-seq]

Project description:To find out differentially expressed mRNAs in OV18h.p.i and OV30h.p.i compared with GSF cells.

2020-03-06 | GSE141163 | GEO

Differentially expressed miRNAs in GSF cells infected by Orf virus at 18h.p.i (OV18h.p.i) and 30h.p.i (OV30h.p.i) compared with the mock-infected GSF cells [miRNA-seq]

Project description:To find out differentially expressed miRNAs in OV18h.p.i and OV30h.p.i compared with GSF cells.

2020-03-06 | GSE141162 | GEO

Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection.

Project description:Orf, caused by Orf virus (ORFV), is a globally distributed zoonotic disease responsible for serious economic losses in the agricultural sector. However, the mechanism underlying ORFV infection remains largely unknown. Circular RNAs (circRNAs), a novel type of endogenous non-coding RNAs, play important roles in various pathological processes but their involvement in ORFV infection and host response is unclear. In the current study, whole transcriptome sequencing and small RNA sequencing were performed in ORFV-infected goat skin fibroblast cells and uninfected cells. A total of 151 circRNAs, 341 messenger RNAs (mRNAs), and 56 microRNAs (miRNAs) were differently expressed following ORFV infection. Four circRNAs: circRNA1001, circRNA1684, circRNA3127 and circRNA7880 were validated by qRT-PCR and Sanger sequencing. Gene ontology (GO) analysis indicated that host genes of differently expressed circRNAs were significantly enriched in regulation of inflammatory response, epithelial structure maintenance, positive regulation of cell migration, positive regulation of ubiquitin-protein transferase activity, regulation of ion transmembrane transport, etc. The constructed circRNA-miRNA-mRNA network suggested that circRNAs may function as miRNA sponges indirectly regulating gene expression following ORFV infection. Our study presented the first comprehensive profiles of circRNAs in response to ORFV infection, thus providing new clues for the mechanisms of interactions between ORFV and the host.

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Differentially expressed miRNAs in GSF cells infected by Orf virus at 18h.p.i (OV18h.p.i) and 30h.p.i (OV30h.p.i) compared with the mock-infected GSF cells [miRNA-seq]

Project description:Differentially expressed miRNAs in GSF cells infected by Orf virus at 18h.p.i (OV18h.p.i) and 30h.p.i (OV30h.p.i) compared with the mock-infected GSF cells [miRNA-seq]

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Differentially expressed miRNAs and mRNAs in GSF cells infected by Orf virus at 18h.p.i (OV18h.p.i) and 30h.p.i (OV30h.p.i) compared with the mock-infected GSF cells

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Differentially expressed mRNAs in GSF cells infected by Orf virus at 18h.p.i (OV18h.p.i) and 30h.p.i (OV30h.p.i) compared with the mock-infected GSF cells [mRNA-seq]

Project description:Differentially expressed mRNAs in GSF cells infected by Orf virus at 18h.p.i (OV18h.p.i) and 30h.p.i (OV30h.p.i) compared with the mock-infected GSF cells [mRNA-seq]

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