Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Blimp1 maintains regulatory T cell identity at sites of inflammation through epigenetic imprinting

ABSTRACT: Blimp1 maintains regulatory T cell identity at sites of inflammation through epigenetic imprinting

PROVIDER: PRJNA498396 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8109570.fastq.gz	Fastqsanger.gz
	SRR8109580.fastq.gz	Fastqsanger.gz
	SRR8109571.fastq.gz	Fastqsanger.gz
	SRR8109581.fastq.gz	Fastqsanger.gz
	SRR8109572.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 19

Similar Datasets

Blimp1 maintains regulatory T cell identity at sites of inflammation through epigenetic imprinting

Project description:Foxp3+ regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity and function. We here establish a transcriptional signature of central nervous system (CNS) Treg cells that accumulate during experimental autoimmune encephalitis (EAE) and identify a pathway that maintains Treg cell function and identity during severe inflammation. This pathway was dependent on the transcriptional regulator Blimp1, which prevented dismantling of Foxp3 expression and "toxic" gain-of-function of Treg cells in the inflamed CNS. Blimp1 negatively regulated IL-6- and STAT3-mediated methylation of Treg cell-specific conserved non-coding sequence 2 (CNS2) in the Foxp3 locus. Consequently, CNS2 was heavily methylated when Blimp1 was ablated, leading to loss of Foxp3 expression and severe disease. These findings identify a Blimp1-dependent epigenetic pathway that preserves Treg cell stability in inflamed non-lymphoid tissues.

2018-10-26 | GSE121764 | GEO

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.

Project description:Foxp3+ regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity and function. Here, we establish a transcriptional signature of central nervous system (CNS) Treg cells that accumulate during experimental autoimmune encephalitis (EAE) and identify a pathway that maintains Treg cell function and identity during severe inflammation. This pathway is dependent on the transcriptional regulator Blimp1, which prevents downregulation of Foxp3 expression and "toxic" gain-of-function of Treg cells in the inflamed CNS. Blimp1 negatively regulates IL-6- and STAT3-dependent Dnmt3a expression and function restraining methylation of Treg cell-specific conserved non-coding sequence 2 (CNS2) in the Foxp3 locus. Consequently, CNS2 is heavily methylated when Blimp1 is ablated, leading to a loss of Foxp3 expression and severe disease. These findings identify a Blimp1-dependent pathway that preserves Treg cell stability in inflamed non-lymphoid tissues.

| S-EPMC6389594 | biostudies-literature

BLIMP1 ChIPseq

Project description:BLIMP1 ChIPseq

| PRJEB1759 | ENA

MafB maintains β-cell identity under MafA-deficient condition

Project description:MafB maintains β-cell identity under MafA-deficient condition

| PRJNA824305 | ENA

BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells

Project description:To clarify the potential BLIMP1 downstream target regulating PD-L1 expression, we performed proteomics analysis using BLIMP1 Hep3B cells and control cells. Proteomics analysis revealed that SPI1 may serve as a pivotal transcriptional factor that enhances PD-L1 expression by acting as a downstream effector of BLIMP1.

2022-11-23 | PXD037621 | Pride

H3K36 methylation maintains cell identity by regulating opposing lineage programs

Project description:H3K36 methylation maintains cell identity by regulating opposing lineage programs

| PRJNA841585 | ENA

H3K36 methylation maintains cell identity by regulating opposing lineage programs

Project description:H3K36 methylation maintains cell identity by regulating opposing lineage programs

| PRJNA840940 | ENA

Tbx5 maintains atrial identity by regulating an atrial enhancer network

Project description:Tbx5 maintains atrial identity by regulating an atrial enhancer network

| PRJNA924314 | ENA

H3K36 methylation maintains cell identity by regulating opposing lineage programs

Project description:H3K36 methylation maintains cell identity by regulating opposing lineage programs