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Transcriptome Data of SREBP2(N) Overexpression in Human Umbilical Vein Endothelial Cells

ABSTRACT: Transcriptome Data of SREBP2(N) Overexpression in Human Umbilical Vein Endothelial Cells

PROVIDER: PRJNA498426 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8110051.fastq.gz	Fastqsanger.gz
	SRR8110052.fastq.gz	Fastqsanger.gz
	SRR8110053.fastq.gz	Fastqsanger.gz
	SRR8110054.fastq.gz	Fastqsanger.gz

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SREBP2(N) Overexpression in Human Umbilical Vein Endothelial Cells

Project description:SREBP2(N) Overexpression in Human Umbilical Vein Endothelial Cells

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Transcriptome Data of SREBP2(N) Overexpression in Human Umbilical Vein Endothelial Cells

Project description:Sterol regulatory element-binding protein 2 (SREBP2) is a transcription factor that has been recently discovered to mediate vascular endothelial cell (EC) dysfunction. We therefore investigated the role of SREBP2 in EC function through comparing the transciptional profiling of human umbilical vein endothelial cells (HUVECs) that were infected with adenovirus overexpressing SREBP2 (Ad-SREBP2) or with empty vector (Ad-null) control. Gene ontology analysis revealed that SREBP2 not only regulates cholesterol biosynthesis, but also mediates the TGF, WNT, and cytoskeleton remodeling pathways. Among the responsive genes, SREBP2 exhibited the induction of mesenchymal transition.

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Chromatin Decondensation Data of SREBP2(N) Overexpression in Human Umbilical Vein Endothelial Cells

Project description:Sterol regulatory element-binding protein 2 (SREBP2) is a transcription factor that has been recently discovered to mediate vascular endothelial cell (EC) dysfunction. We therefore investigated the role of SREBP2 in the epigenetic function of EC biology through comparing ATAC-seq of human umbilical vein endothelial cells (HUVECs) that were infected with adenovirus overexpressing SREBP2 (Ad-SREBP2) or with empty vector (Ad-null) control. Gene ontology analysis revealed that SREBP2 not only decondenses chromatin for cholesterol biosynthesis, but also mediates the TGF pathway. Among the responsive promoter, SREBP2 exhibited the induction of genes related to mesenchymal transition.

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Chromatin Decondensation Data of SREBP2(N) Overexpression in Human Umbilical Vein Endothelial Cells

Project description:Chromatin Decondensation Data of SREBP2(N) Overexpression in Human Umbilical Vein Endothelial Cells

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Project description:Atheroprotective flow (e.g., pulsatile shear stress) and statins drastically induce the expression of krüppel-like factor 4 (KLF4) in vascular endothelial cells (ECs). We therefore investigated the role of KLF4 in EC function through comparing the transciptional profiling of human umbilical vein endothelial cells (HUVECs) that were infected with adenovirus overexpression KLF4 (Ad-KLF4) or with empty vector (Ad-null) control. Gene ontology analysis revealed that KLF4 not only regulates EC homeostasis through the upregulation of nitric oxide synthesis and vascular development, but also mediates response to lipid. Among the lipid responsive genes, KLF4 exhibited induction of cholesterol efflux and oxidation [i.e., liver X receptor (LXR) and cholesterol 25-hydroxylase (Ch25h)], while suppressing cholesterol biosynthesis [i.e., sterol regulatory element-binding protein 2 (SREBP2)].

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