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SIX4 acts as a master regulator of genes associated with the malignant phenotype of non-small cell lung cancer cells

ABSTRACT: SIX4 acts as a master regulator of genes associated with the malignant phenotype of non-small cell lung cancer cells

PROVIDER: PRJNA498677 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8114390_1.fastq.gz	Fastqsanger.gz
	SRR8114390_2.fastq.gz	Fastqsanger.gz
	SRR8114391_1.fastq.gz	Fastqsanger.gz
	SRR8114391_2.fastq.gz	Fastqsanger.gz
	SRR8114392_1.fastq.gz	Fastqsanger.gz

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SIX4 acts as a master regulator of genes associated with the malignant phenotype of non-small cell lung cancer cells

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Project description:We report that the PRC1 component polycomb group ring finger 6 (Pcgf6) is required to maintain embryonic stem cell (ESC) identity. In contrast to canonical PRC1, Pcgf6 acts as a positive regulator of transcription and binds predominantly to promoters bearing active chromatin marks.Â Pcgf6Â is expressed at high levels in ESCs, and knockdown reduces the expression of the core ESC regulatorsÂ Oct4,Sox2, andÂ Nanog. Conversely,Â Pcgf6Â overexpression prevents downregulation of these factors and impairs differentiation. In addition, Pcgf6 enhanced reprogramming in both mouse and human somatic cells. The genomic binding profile of Pcgf6 is highly similar to that of trithorax group proteins, but not of PRC1 or PRC2 complexes, suggesting that Pcgf6 functions atypically in ESCs. Our data reveal novel roles for Pcgf6 in directly regulatingÂ Oct4,Â Nanog,Â Sox2, andÂ Lin28 expression to maintain ESC identity. To identify Pcgf6-bound genomic DNA regions in mouse embryonic stem cells, we fixed mouse ESCs and isolated Pcgf6-bound genomic DNA regions for deep sequencing analysis.

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