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TNF-alpha-stimulated human umblical vein endothelial cells (HUVECs)

ABSTRACT: TNF-alpha-stimulated human umblical vein endothelial cells (HUVECs)

PROVIDER: PRJNA501790 | ENA |

REPOSITORIES: ENA

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Hi-C analysis in TNF-alpha-stimulated human umblical vein endothelial cells (HUVECs)

Project description:Hi-C analysis in TNF-alpha-stimulated human umblical vein endothelial cells (HUVECs)

| PRJNA497537 | ENA

miRNA expression data through TNF-alpha-signaling in human umblical vein endothelial cells (HUVECs)

Project description:miRNA expression data through TNF-alpha-signaling in human umblical vein endothelial cells (HUVECs)

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Chromatin Interaction Analysis by Paired-End Tag Sequencing (ChIA-PET) analysis in TNF-alpha-stimulated human umblical vein endothelial cells (HUVECs)

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Hi-C analysis in TNF-alpha-stimulated human umblical vein endothelial cells (HUVECs)

Project description:Lysine 9 di-methylation and lysine 27 tri-methylation of histone H3 (H3K9me2 and H3K27me3) are mostly linked to gene repression. However, functions of repressive histone methylation dynamics during inflammatory responses remain poorly understood. Here, we show that lysine demethylase 7A (KDM7A) and 6A (UTX) are rapidly transported to nuclear factor kappa-B (NF-κB) related elements in human endothelial cells in response to tumor necrosis factor (TNF)-α. KDM7A and UTX demethylate H3K9me2 and H3K27me3, respectively, and cooperatively activate NF-κB dependent inflammatory genes. Furthermore, using both in situ Hi-C and other 3C based technology, loops between super enhancers (SEs) are newly formed following TNF-α-stimuli at NF-κB-dependent inflammatory loci where KDM7A- and UTX-recruitment coincide. Collectively, these findings suggest that erasing of repressive histone marks by KDM7A and UTX within NF-κB-related elements might functionally associate with formation of SE-SE three-dimensional interactions and could be a cue signal during inflammatory responses in human endothelial cells.

2019-04-11 | GSE121520 | GEO

TNF-alpha-stimulated human umblical vein endothelial cells (HUVECs)

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-04-11 | GSE121522 | GEO

Comprehensive gene expression analysis of TNF-alpha-stimulated human umbilical vein endothelial cells (HUVECs)

Project description:Comprehensive gene expression analysis of TNF-alpha-stimulated human umbilical vein endothelial cells (HUVECs)

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comprehensive chromatin interaction in TNF alpha stimulated HUVECs

Project description:HUVECs were stimulated and samples were prepared after 0 and 30 min. Chromatin interaction mediated by active RNA polymerase II was detected by ChIA-PET. Samples were made afrer 0 and 30 min after TNF alpha stimulation.

2012-10-13 | E-GEOD-41553 | biostudies-arrayexpress

miRNA expression data through TNF-alpha-signaling in human umblical vein endothelial cells (HUVECs)

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Chromatin Interaction Analysis by Paired-End Tag Sequencing (ChIA-PET) analysis in TNF-alpha-stimulated human umblical vein endothelial cells (HUVECs)

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Genome-wide maps of RNA Polymerase II and p65 localization in HUVECs stimulated with TNF alpha

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2013-01-01 | E-GEOD-34500 | biostudies-arrayexpress

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