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Exophiala dermatitidis

ABSTRACT: A melanized yeast

PROVIDER: PRJNA50181 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
		Other
	AFPA01.dat.gz	Other
	AFPA01.fasta.gz	Fasta.gz
	AFPA01.master.dat	Other
	JAJGCB01.dat.gz	Other

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1 - 5 of 276

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The response of the melanized yeast Exophiala dermatitidis to gamma radiation exposure

Project description:The melanized yeast Exophiala dermatitidis is resistant to many environmental stresses, and is used as a model for understanding the diverse roles of melanin in fungi. To further our understanding resistance mechanism of E. dermatitidis to acute γ-radiation exposure and whether melanin plays a role in this process, we performed RNA-seq on WT and the melanin deficient mutant Δpks1 cultures exposed to γ-radiation at the dose of 1000 Gy, which resulted in ~50% cell deaths in both strains. We observed a dramatic transcriptomic response to γ-radiation that mobilizes pathways involved in morphological development, protein degradation, and DNA repair, and is unaffected by the presence of melanin.

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Peritonitis by <i>Exophiala dermatitidis</i> in a pediatric patient.

Project description:Fungal peritonitis is frequent on peritoneal dialysis, with rare cases by Exophiala dermatitidis. A 25-month-old female admitted to the pediatric ICU with acute renal failure was submitted to peritoneal dialysis. After 10 days patient presented fever. Peritoneal fluid culture showed yeast colonies molecularly identified as E. dermatitidis. Patient was treated with voriconazole and hemodialysis. The literature was reviewed. Disseminated infections are frequently fatal, but appropriate diagnose and therapeutic led to cure in this case.

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