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Gene expression profiling of basal and luminal epithelial cells from young adult and old mouse prostates

ABSTRACT: Gene expression profiling of basal and luminal epithelial cells from young adult and old mouse prostates

PROVIDER: PRJNA504794 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8179100.fastq.gz	Fastqsanger.gz
	SRR8179101.fastq.gz	Fastqsanger.gz
	SRR8179102.fastq.gz	Fastqsanger.gz
	SRR8179103.fastq.gz	Fastqsanger.gz
	SRR8179104.fastq.gz	Fastqsanger.gz

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Gene expression profiling of basal and luminal epithelial cells from young adult and old mouse prostates

Project description:We set out to determine if prostate epithelial cell-types exhibited age-related differences in their gene expression profiles. We used fluorescence activated cell sorting to isolate basal and luminal cells from dissociated preparations of prostate tissue taken from young adult (3 months) and old (24 months of age) mice. RNA was extracted from sorted cells to evaluate differences in gene expression. We found significant enrichment for progenitor genes in old luminal cells including an immune/inflammatory profile that overlapped with a previously identified CD38-lo human prostate luminal progenitor signature. This study demonstrates a luminal progenitor signature in old mouse prostate.

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Gene expression profiling of Trop2+ and Trop2- luminal epithelial cells and stromal cells from young adult and old mouse prostates

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Project description:We present the results of a microarray analysis in which we compare gene expression in CFP+ basal and CFP- luminal epithelia cell populations derived from whole prostates of CK5/CFP adult mice. Several genes that have previously been identified as potential stem cell markers in stem cells from various organs are over-expressed in CFP+ cells relative to CFP- cells.

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Project description:To further characterize the molecular and biological features of the Sca-1+ luminal cells, we performed an RNA-seq analysis using FACS-isolated distinct cell lineages in adult mouse prostates, including the Lin-CD24lowCD49fhigh basal cells, Lin-CD24-CD49f- stromal cells, Lin-CD24highCD49flowSca-1- luminal cells, and Lin-CD24highCD49flowSca-1+ luminal cells.

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