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RNA-seq and microRNA-seq reveal RNAs and microRNAs under the regulation of miR-125b in NCCIT tumor cells

ABSTRACT: RNA-seq and microRNA-seq reveal RNAs and microRNAs under the regulation of miR-125b in NCCIT tumor cells

PROVIDER: PRJNA507719 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8261300.fastq.gz	Fastqsanger.gz
	SRR8261301.fastq.gz	Fastqsanger.gz
	SRR8265811.fastq.gz	Fastqsanger.gz
	SRR8261302.fastq.gz	Fastqsanger.gz
	SRR8265812.fastq.gz	Fastqsanger.gz

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microRNA-seq reveals microRNAs under the regulation of miR-125b in NCCIT tumor cells

Project description:To investigate the role and mechanism of miR-125b on NCCIT cells without bias, we analyzed differentially expression microRNA profile among miR-125b antagomir-, miR-125b agomir-, and negative control-transfected NCCIT tumor cells by microRNA-seq.

2018-11-30 | GSE123156 | GEO

RNA-seq reveals RNAs under the regulation of miR-125b in NCCIT tumor cells

Project description:To investigate the role and mechanism of miR-125b on NCCIT cells without bias, we analyzed differentially expression RNA profile among miR-125b antagomir-, miR-125b agomir-, and negative control-transfected NCCIT tumor cells by RNA-seq.

2018-11-30 | GSE123113 | GEO

microRNA-seq reveals microRNAs under the regulation of miR-125b in NCCIT tumor cells

Project description:microRNA-seq reveals microRNAs under the regulation of miR-125b in NCCIT tumor cells

| PRJNA507722 | ENA

RNA-seq reveals RNAs under the regulation of miR-125b in NCCIT tumor cells

Project description:RNA-seq reveals RNAs under the regulation of miR-125b in NCCIT tumor cells

| PRJNA507586 | ENA

RNA-seq and microRNA-seq reveal RNAs and microRNAs under the regulation of miR-125b in NCCIT tumor cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-11-30 | GSE123157 | GEO

Effect of GDF3 on NCCIT cells

Project description:The aim of the study was to characterize the role of GDF3 in NCCIT cells as a model of cancer stem cells. The NCCIT cells were stimulated for 3h with (1) 100ng/mL and (2) 300ng/mL GDF3, (3) 300ng/mL Nodal and (4) 100ng/mL GDF3 + 300ng/mL Nodal and compared to unstimulated control. Additionally a stable, lentiviral knockdown of GDF3 was performed in NCCIT cells and the transciption profile of these cells was compared to cells transduced with mock-virus.

2013-02-27 | GSE44670 | GEO

hDot1L and RNAPII-5p in NCCIT cells.

Project description:We generated high-throughput sequencing (ChIP-seq) data for genome wide occupancy of hDot1L and RNAPII-5p in human embryonic carcinoma cell. Performing ChIP-seq for hDot1L and RNAPII-5p in NCCIT cell lines (embryonic carcinoma cell lines in human).

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microRNA-125b Promotes Neuronal Differentiation in Human Cells by Repressing Multiple Targets

Project description:We report here the expression profile of microRNAs in human neuronal differentiation in the neuroblastoma cell line SH-SY5Y. Six microRNAs were significantly upregulated during differentiation induced by all-trans¬-retinoic acid and brain-derived neurotrophic factor. We demonstrated that ectopic expression of either miR-124a or miR-125b increases the percentage of differentiated SH-SY5Y cells with neurite outgrowth. Subsequently, we focused our functional analysis on miR-125b and demonstrated the important role of this miRNA in both spontaneous and induced differentiation of SH-SH5Y cells, based on neurite outgrowth and neuronal marker expression. In human neural progenitor ReNcell VM cells, miR-125b is also upregulated during differentiation and miR-125b ectopic expression significantly promotes neurite outgrowth. To identify the targets of miR-125b regulation, we profiled the global changes in gene expression following miR-125b ectopic expression in SH-SY5Y cells. miR-125b represses 164 genes that contain the seed match sequence of the microRNA and/or predicted to be direct targets of miR-125b by conventional methods. Pathway analysis suggests that a subset of miR-125b-repressed targets antagonize neuronal genes in several neurogenic pathways, thereby mediating the positive effect of miR-125b on neuronal differentiation. We have further validated the binding of miR-125b to the microRNA response elements of ten selected targets. Together, we report here for the first time the important role of miR-125b in human neuronal differentiation. Keywords: mir125-OE/mir-scrambled control comparison & mir125-KD/mir-scrambled control comparsion

2009-02-12 | GSE14787 | GEO

Effect of GDF3 on NCCIT cells

2013-02-27 | E-GEOD-44670 | biostudies-arrayexpress

RNA sequencing data of NCCIT cells deficient for CD24 and parental controls

Project description:Single eng 3' RNA sequencing of embryonal carcinoma cell line NCCIT deficient for CD24 and parental cells. CD24 deficiency was genereted by CRISPR/Cas9 method. Five different NCCIT knock out clones were sequenced.

2021-08-01 | GSE168646 | GEO

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