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Histone modifications (H3K4me1, H3K4me3, and H3K27ac) in IGF-2-preprogrammed macrophages and control macrophages

ABSTRACT: Histone modifications (H3K4me1, H3K4me3, and H3K27ac) in IGF-2-preprogrammed macrophages and control macrophages

PROVIDER: PRJNA507778 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8268220_1.fastq.gz	Fastqsanger.gz
	SRR8268220_2.fastq.gz	Fastqsanger.gz
	SRR8268221_1.fastq.gz	Fastqsanger.gz
	SRR8268221_2.fastq.gz	Fastqsanger.gz
	SRR8268222_1.fastq.gz	Fastqsanger.gz

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Histone modifications (H3K4me1, H3K4me3, and H3K27ac) in IGF-2-preprogrammed macrophages and control macrophages

Project description:Macrophages with innate immune memory are in a modified steady-status with altered responsiveness to stimulation featured by rewired epigenetic program. To better convey the concept of IGF-2-mediated innate immune memory and help understanding the anti-inflammatory responsiveness of macrophages, we analyzed histone modifications (H3K4me1, H3K4me3, and H3K27ac) by whole genome chip-sequencing analysis in control macrophages and IGF-2-preprogrammed macrophages. In the whole genome chip-sequencing analysis, we found that IGF-2 has limited effects on H3K4me1and H3K4me3, but mainly modulates H3K27ac status during macrophages maturation.

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Project description:To study the tissue-specific evolution of regulatory elements in the mammalian lineage, we created a comprehensive map of promoters and enhancers in 4 tissues of 10 mammalian species. To map in-vivo promoters and enhancers, we performed ChIP-seq experiments for H3K4me3, H3K27ac and H3K4me1 in adult liver, muscle, brain and testis of all 10 species. The species included in the study are: macaque, marmoset, mouse, rat, rabbit, pig, dog, cat, horse and opossum. To correlate regulatory evolution to expression, we also performed RNA-seq experiments in all tissues and species submitted separately to ArrayExpress.

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