Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: dynamic alterations in gut microbiota of collagen-induced arthritis rats

PROVIDER: PRJNA507839 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8269490_1.fastq.gz	Fastqsanger.gz
	SRR8269490_2.fastq.gz	Fastqsanger.gz
	SRR8269500_1.fastq.gz	Fastqsanger.gz
	SRR8269500_2.fastq.gz	Fastqsanger.gz
	SRR8269510_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 220

Similar Datasets

Project description:gut microbiota of collagen-induced arthritis rats

| PRJNA506806 | ENA

The differentially expressed lncRNAs (DELs) and mRNAs (DEMs) in Collagen-induced arthritis rats compared with normal rats.

Project description:To determine te lncRNA expression profile in collagen-induced arthritis rats and normal rats, we uesed lncRNA microArray analysis form Arraystar to examine the expression of lncRNAs in CIA and normal rats' synovial tissues.

2022-11-16 | GSE206097 | GEO

Regulation of Microglia-Mediated Neuroinflammation Post-Intracerebral Hemorrhage by Gut Microbiota and Short-Chain Fatty Acid Metabolism

Project description:Intracerebral hemorrhage (ICH) induces alterations in the gut microbiota composition, significantly impacting neuroinflammation post-ICH. However, the impact of gut microbiota absence on neuroinflammation following ICH-induced brain injury remain unexplored. Here, we observed that the gut microbiota absence was associated with reduced neuroinflammation, alleviated neurological dysfunction, and mitigated gut barrier dysfunction post-ICH. In contrast, recolonization of microbiota from ICH-induced SPF mice by transplantation of fecal microbiota (FMT) exacerbated brain injury and gut impairment post-ICH. Additionally, microglia with transcriptional changes mediated the protective effects of gut microbiota absence on brain injury, with Apoe emerging as a hub gene. Subsequently, Apoe deficiency in peri-hematomal microglia was associated with improved brain injury. Finally, we revealed that gut microbiota influence brain injury and gut impairment via gut-derived short-chain fatty acids (SCFA).

2024-05-13 | GSE266602 | GEO

Project description:All-trans retinoic acid alleviates collagen-induced arthritis in rats through gut-joint axis

| PRJNA1021952 | ENA

Dynamic changes of the gut microbiota within a new Alzheimer’s Disease rat model using multi-omics approaches

Project description:We collected 19 colon content samples from wild-type and new AD models (AppNL-G-F rats) at 3 and 12 months of age and profiled the composition and functionality of gut microbiota using multi-omics approaches. Using the newly emerged proteomics method, data-independent acquisition (DIA), integrated with a sample-matched database, we detected the significantly differentially expressed microbial proteins and observed the functional alterations of gut microbiota at gene ontology (GO), Enzyme Commission (EC) and Clusters of orthologous groups (COG) levels. Our multi-omics study provided a more detailed comprehensive picture of the dynamic gut microbiota at the over-all molecular level.

2022-06-20 | PXD034707 |

Consequences of collagen induced inflammatory arthritis on circadian regulation of the gut microbiome.

Project description:Autoimmune diseases, such as rheumatoid arthritis, are associated with significant gut microbiota dysbiosis. Here we show that remodelling of 24h rhythms within the gut during inflammatory joint disease drives profound changes in the microbiome and gut permeability.

2023-03-15 | GSE184233 | GEO

Gut microbiota analysis of colitic SD rats

Project description:Fecal samples collected on day 5 from randomly selected colitic SD rats were analyzed for gut microbiota by sequencing the V4 region of the 16S rRNA gene. The orally administered Dex-P-laden NPA2 coacervate (Dex-P/NPA2) significantly restores the diversity of gut microbiota compared with colitic SD rats in the Dex-P/PBS group and the untreated colitic rats (Control).

2021-11-06 | GSE167138 | GEO

Collagen induced arthritis in dba/1j mice associates with oxylipin changes in plasma

Project description:Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range of diseases such as rheumatoid arthritis (RA). The purpose of this research was to study differences in oxylipin levels between a widely used collagen-induced arthritis (CIA) mice model and healthy control (Ctrl) mice. DBA/1J male mice (age: 6-7 weeks) were selected and randomly divided into two groups, viz. a CIA- and a Ctrl group. The CIA mice were injected intraperitoneal (i.p.) with the joint cartilage component collagen type II (CII) and an adjuvant injection of lipopolysaccharide (LPS). Oxylipin metabolites were extracted from plasma for each individual sample using solid phase extraction (SPE) and were detected with high performance liquid chromatography/tandem mass spectrometry (HPLC-ESI-MS/MS), using dynamic multiple reaction monitoring (dMRM). Both univariate and multivariate statistical analysis was applied. The results in univariate student's t-test revealed 10 significantly up- or down-regulated oxylipins in CIA mice, which were supplemented by another 6 additional oxylipins, contributing to group clustering upon multivariate analysis. The dysregulation of these oxylipins revealed the presence of ROS-generated oxylipins and an increase of inflammation in CIA mice. The results also suggested that the Collagen-induced arthritis might associate with dysregulation of apoptosis, possibly inhibited by activated NF- κ B because of insufficient PPAR-γ ligands.

2015-11-04 | MTBLS243 | MetaboLights

Project description:Bifidobacterium breve CCFM1078 Alleviates Collagen-Induced Arthritis in Rats via Modulating the Gut Microbiota and Repairing the Intestinal Barrier Damage

| PRJNA838246 | ENA

Project description:Gut microbiota diversity in rats with arthritis induced by complete Freund's adjuvant

| PRJNA929309 | ENA