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Transcriptomic analysis of mRNA expression changes in the murine thymus induced by RANKL expression

ABSTRACT: Transcriptomic analysis of mRNA expression changes in the murine thymus induced by RANKL expression

PROVIDER: PRJNA508777 | ENA |

REPOSITORIES: ENA

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Transcriptomic analysis of mRNA expression changes in the murine thymus induced by RANKL expression

Project description:Sequencing of mRNA isolated from the thymus of control mice and mice overexpressing RANKL in keratin 5 (K5)-positive cells for 1 weeks.

2022-12-05 | GSE123450 | GEO

Transcriptomic analysis of mRNA expression changes induced by RANKL expression in the murine salivary gland

Project description:Transcriptomic analysis of mRNA expression changes induced by RANKL expression in the murine salivary gland

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Transcriptomic analysis of mRNA expression changes induced by RANKL expression in the murine salivary gland

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Gene expression profile of murine intestinal epithelial cells after RANKL treatment

Project description:RANKL (receptor acrivator of NFkB ligand) is a member of TNF superfamily cytokines. In the gastrointestinal tract, RANKL is expressed in the stromal cells of Peyer's patches, and involved in the development of the specialized intestinal epithelial cells, called M cells. To identify the genes involved in M-cell development, we treated BALB/c mice with recombinant GST-RANKL. After RANKL-treatment, epithelial cells were isolated from small intestine, and used for microarray analysis. Total of 15 samples were analyzed. We generated the Excel sheet for comparing gene expression.

2012-06-16 | E-GEOD-37861 | biostudies-arrayexpress

Gene expression profile of murine intestinal epithelial cells after RANKL treatment

2012-06-17 | GSE37861 | GEO

Murine Bone Marrow Macrophages: Control vs. RANKL Stimulated

Project description:To identify the microRNAs that are involved in osteoclastogenesis, microRNA expression profiles in mouse bone marrow macrophages (BMMs) stimulated with RANKL (BMOc) were compared with that of control untreated BMMs. These results provide insights into the mechanisms to regulate osteoclastogenesis and bone resorption activities in osteoclasts by microRNA. BMMs were cultured with 20 ng/ml M-CSF in the presence or absence of 50 ng/ml RANKL for 24 hours. Cells were collected for total RNA isolation, and were subjected to microRNA array analysis.

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Murine Bone Marrow Macrophages: Control vs. RANKL Stimulated

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Expression data from mouse thymus

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Expression data of RANKL-deficient CCR6+ ILC3

Project description:Expression data of RANKL-deficient CCR6+ ILC3

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Single-cell RNA sequencing of thymic EC and TEC from control and RANKL treated aged mice

Project description:Age-related thymic involution is one of the major causes of immunosenescence, characterized by reduced production of naive T cells, leading to increased susceptibility to cancers, infections, autoimmunity and reduced vaccine efficacy. Here, we reveal that the RANK/RANKL axis is altered in the thymus during aging, which results in a decline in thymic epithelial cell (TEC) and endothelial cell (EC) function and, consequently, to thymic involution. Whereas RANKL neutralization in young mice mimics thymic involution, RANKL treatment in aged individuals restores the thymic architecture, TEC and EC functional properties, and thymic T-cell production. This cascade of events results in peripheral T cell renewal and effective anti-tumor and anti-viral immune responses. Furthermore, we provide the proof-of-concept that RANKL stimulates TEC and EC in human thymic organo-cultures. Collectively, our findings identify RANKL administration as a potent therapeutic strategy to rejuvenate thymic function and improve T-cell immune function in the elderly.

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