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Longitudinal tracking of whole blood gene-expression in healthy young and old individuals - 2014

ABSTRACT: Longitudinal tracking of whole blood gene-expression in healthy young and old individuals - 2014

PROVIDER: PRJNA509614 | ENA |

REPOSITORIES: ENA

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Longitudinal tracking of whole blood gene-expression in healthy young and old individuals - 2014

Project description:Immune responses generally decline with age. We used multiple ‘omics’ technologies to capture population- and individual- level changes in the human immune system of 135 healthy adult individuals of different ages sampled longitudinally over a nine-year period. We observe a high inter-individual variability in the rates of change of cellular frequencies that correlate with baseline values, allowing identification of steady state levels towards which a cell subset converges and the ordered convergence of multiple cell subsets towards an older adult homeostasis. These form a high dimensional trajectory of immune-aging (IMM-AGE) that describes a person’s immune status better than chronological age. We show the IMM-AGE score predicts all-cause mortality beyond well-established risk factors in the Framingham Heart Study.

2018-12-13 | GSE123697 | GEO

Longitudinal tracking of whole blood gene-expression in healthy young and old individuals - 2015

Project description:Longitudinal tracking of whole blood gene-expression in healthy young and old individuals - 2015

| PRJNA509613 | ENA

Longitudinal tracking of whole blood gene-expression in healthy young and old individuals - 2013

Project description:Longitudinal tracking of whole blood gene-expression in healthy young and old individuals - 2013

| PRJNA509612 | ENA

Longitudinal tracking of whole blood gene-expression in healthy young and old individuals - 2015

2018-12-13 | GSE123698 | GEO

Longitudinal tracking of whole blood gene-expression in healthy young and old individuals - 2013

2018-12-13 | GSE123696 | GEO

GNPS Old Sputum Longitudinal

Project description:Longitudinal sputum samples collected from multiple patients in 2011-2012

2016-01-05 | MSV000079443 | GNPS

Longitudinal landscape of urinary EV proteome reveals stable protein expression patterns within and between individuals

Project description:Urinary extracellular vesicles (EVs) are an attractive source for the detection of disease biomarkers. Mass spectrometry (MS) based proteomics is increasingly used for urinary EV proteome profiling and protein biomarker discovery. However, little is known about the consistency and stability of urinary EV proteins within individuals over time and between different individuals. In this study we profiled the urinary EV proteome of 8 healthy individuals over 6 months at 9 timepoints (total 72 samples) using DIA-MS. We identified a total of 1802 proteins with high correlation amongst all samples. While a minor fraction (10%) of the total urinary EV proteome was shown to play a role in determining personal expression patterns, most of the urinary EV proteins was found to be stable with >90% of the proteins detected in more than 1 person at all timepoints. The variability of urinary EV proteome between different individuals was shown to be significantly higher than personal variation as a result of a small subset (<20%) of proteins. The core interaction network of proteins identified in all individuals revealed EV proteins involved in signaling and localization and sub-clusters enriched for glycolytic activity, protein synthesis, and immune function. Gender-specific expression patterns were detected in the urinary EV proteome, mostly related to hormonal and reproduction pathways. In summary, our findings indicate that the urinary EV proteome is stable in longitudinal samples of healthy subjects, underscoring its potential as a reliable source for protein biomarkers.

2021-09-09 | PXD022983 | Pride

RNAseq of old and young Macrotermes bellicosus (Blattodea, Isoptera) individuals

Project description:Examination of aging in social insects. Differential gene expression between old and young individuals of four castes of the termite Macrotermes bellicosus. Minor workers, major workers, kings, queens. Collected in January 2015 in Ivory Coast.

2018-04-26 | E-MTAB-6767 | biostudies-arrayexpress

RNAseq of old and young Macrotermes bellicosus (Blattodea, Isoptera) individuals

Project description:RNAseq of old and young Macrotermes bellicosus (Blattodea, Isoptera) individuals

| PRJEB26378 | ENA

Calpastatin in erythrocytes of young and old individuals.

Project description:To gain knowledge about the behaviour of calpastatin (the specific inhibitor of the Ca(2+)-dependent thiol protease calpain) in the intact cell, we analysed the inhibitor by specific antibodies and determined its activity in erythrocytes from individuals 20-34 years old (young) and 70-93 years old (old). Differences between old and young in the behaviour of erythrocyte calpastatin were observed. Erythrocytes of old individuals had lower amounts of calpastatin and less calpastatin activity than those of young ones. A difference between old and young was also found in the molecular-mass distribution of calpastatin subunits. Increasing the erythrocyte Ca2+ induced changes in calpastatin in young individuals, rendering it similar to calpastatin in cells of old individuals. When calpastatin (isolated from erythrocytes of a young individual) was added to erythrocyte membranes, the initial binding and subsequent association of calpastatin with the membrane were lower in old than in young individuals. We had previously found that calpain binding and activation were enhanced in erythrocyte membranes from old individuals, along with enhanced degradation of band 3 (a major erythrocyte transmembrane anion-transport protein). The overall results indicate an interaction of calpain with calpastatin in the intact cell. Enhanced activation of erythrocyte calpain and degradation of calpastatin occur under conditions of increased cellular Ca2+ and in cells of the aged.

| S-EPMC1137502 | biostudies-other

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