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Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia

ABSTRACT: Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia

PROVIDER: PRJNA510364 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8329260.fastq.gz	Fastqsanger.gz
	SRR8329270.fastq.gz	Fastqsanger.gz
	SRR8329280.fastq.gz	Fastqsanger.gz
	SRR8329290.fastq.gz	Fastqsanger.gz
	SRR8329261.fastq.gz	Fastqsanger.gz

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Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia

Project description:Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations of gene expression that are typically associated with cell adhesion, migration, and differentiation. A high expression is associated with DNA hypomethylation at the SOX11 locus and a favorable outcome. The results indicate that SOX11 expression marks a group of patients with good outcomes and thereby prompts further study of its use as a biomarker.

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