Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cryptococcus gattii VGII

ABSTRACT: Cryptococcus gattii VGII Genome sequencing and assembly

PROVIDER: PRJNA511460 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR23862314_1.fastq.gz	Fastqsanger.gz
	SRR23862314_2.fastq.gz	Fastqsanger.gz
	SRR23862315_1.fastq.gz	Fastqsanger.gz
	SRR23862315_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 90

Similar Datasets

Cryptococcus deuterogattii

Project description:Cryptococcus deuterogattii Genome sequencing and assembly

| PRJNA388113 | ENA

Cryptococcus deuterogattii

Project description:Cryptococcus deuterogattii Genome sequencing

| PRJNA387047 | ENA

Cryptococcus deuterogattii strain:CBS10090

Project description:Cryptococcus deuterogattii strain:CBS10090 Genome sequencing and assembly

| PRJNA1075796 | ENA

Cryptococcus deuterogattii strain:VGII

Project description:Cryptococcus deuterogattii strain:VGII Genome sequencing

| PRJNA254979 | ENA

Extracellular vesicle formation in Cryptococcus deuterogattii impacts fungal virulence

Project description:Small molecules are components of fungal extracellular vesicles (EVs), but their biological roles are only superficially known. NOP16 is a eukaryotic gene that is required for the activity of benzimidazoles against Cryptococcus deuterogattii. In this study, during the phenotypic characterization of C. deuterogattii mutants expected to lack NOP16 expression, we observed a reduced EV production. Whole-genome sequencing, RNAseq, and cellular proteomics revealed that, contrary to our initial findings, these mutants expressed Nop16 but exhibited altered expression of 14 genes potentially involved in sugar transport. Based on this observation, we designated these mutants as past1 and past2, representing potentially altered sugar transport. Analysis of the small molecule composition of EVs produced by wild-type cells and the past1 and past2 mutants revealed not only a reduced number of EVs but also an altered small molecule composition. In a Galleria mellonella model of infection, the past1 and past2 mutants were hypovirulent. The hypovirulent phenotype was reverted when EVs produced by wild-type cells, but not mutant EVs, were co-injected with the mutant cells in G. mellonella. These results connect EV biogenesis, cargo and cryptococcal virulence.

2024-02-29 | PXD048601 | Pride

Cryptococcus deuterogattii CA1014

Project description:Cryptococcus Sequencing

| PRJNA191329 | ENA

Cryptococcus deuterogattii LA55

Project description:Cryptococcus Sequencing

| PRJNA191328 | ENA

Cryptococcus deuterogattii MMRL2647

Project description:Cryptococcus Sequencing

| PRJNA191372 | ENA

Cryptococcus deuterogattii Ram5

Project description:Cryptococcus Sequencing