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Next generation sequencing analysis of transcriptomes at different timepoints after chlorprothixene treatment in NB4 and Kasumi-1 cells

ABSTRACT: Next generation sequencing analysis of transcriptomes at different timepoints after chlorprothixene treatment in NB4 and Kasumi-1 cells

PROVIDER: PRJNA511587 | ENA |

REPOSITORIES: ENA

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Next generation sequencing analysis of transcriptomes at different timepoints after chlorprothixene treatment in NB4 and Kasumi-1 cells

Project description:To understand the mechanisms of chlorprothixene in acute myeloblastic leukemia (AML) therapy, gene expression changes of NB4 and Kasumi-1cells after chlorprothixene treatment were analyzed by RNA-seq

2019-12-23 | GSE124316 | GEO

mRNA expression quantitative Analysis of NB4 and Kasumi-1 treated with OGP46 compared with control

Project description:The goals of this study are toevaluate the mRNA expressions of genes in NB4 and Kasumi-1 cell lines treated with OGP46

2021-03-23 | GSE167084 | GEO

mRNA expression quantitative Analysis of Kasumi-1 and NB4 treated with JOA compared with control

Project description:The goals of this study are toevaluate the mRNA expressions of genes in Kasumi-1 and NB4 cell lines treated with JOA

2023-06-30 | GSE210200 | GEO

Next Generation Sequencing Quantitative Analysis of 0.5% BSA and IL10 treated Kasumi-1 cells' Transcriptomes

Project description:Examination the gene expression profile changes of Kasumi-1 cells treated with rhIL10.

2021-09-30 | GSE158721 | GEO

Next Generation Sequencing Quantitative Analysis of Wild Type and AML1-ETO Related Fusion Circular RNA (F-CircAE) Knockdown Kasumi-1 Cells Transcriptomes

Project description:The goal of this study is to determine the difference in transcriptome expression profils between wild type and AML1-ETO related fusion circular RNA knockdown Kasumi-1 cells

2019-01-15 | GSE125043 | GEO

mRNA expression quantitative Analysis of Kasumi-1 and NB4 treated with JOA compared with control

Project description:mRNA expression quantitative Analysis of Kasumi-1 and NB4 treated with JOA compared with control

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mRNA expression quantitative Analysis of NB4 and Kasumi-1 treated with OGP46 compared with control

Project description:mRNA expression quantitative Analysis of NB4 and Kasumi-1 treated with OGP46 compared with control

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KASUMI-1ctrl vs KASUMI-1 Saha (Vorinostat; suberoylanilide hydroxamic acid) 6h

Project description:miRNA expression profiling of KASUMI-1 ctrl vs KASUMI-1 treated Saha 5 µM 6h

2017-05-22 | GSE69956 | GEO

Genome-wide map of JMJD1C binding in Kasumi-1 cells [ChIP-seq]

Project description:The AML1-ETO fusion protein, a transcription factor generated by the t(8;21) translocation in acute myeloid leukaemia (AML), dictates a leukemic program by increasing self-renewal and inhibiting differentiation. Here we demonstrate that the histone demethylase JMJD1C functions as a co-activator for AML1-ETO and is required for its transcriptional program. JMJD1C is directly recruited by AML1-ETO to its target genes and regulates their expression by maintaining low H3K9me2 levels. Analyses in JMJD1C knockout mice also establish a JMJD1C requirement for AML1-ETOâs ability to increase proliferation. We also show a critical role for JMJD1C in the survival of multiple human AML cell lines, suggesting that it is required for leukemic programs in different AML cell types through its association with key transcription factors. Examination of JMJD1C and LYL1 chromatin binding in Kasumi-1 cells, HL-60 cells, NB-4 cells and THP-1 cells, including ChIP-seqs of JMJD1C and LYL1, and input DNAs for Kasumi-1, HL-60, NB4.

2015-11-02 | E-GEOD-63484 | biostudies-arrayexpress

Next Generation Sequencing Facilitates Quantitative Analysis of CP5322-treated and Non-treated Transcriptomes in Kasumi-1 cells

Project description:Purpose: The goals of this study are designed to study the alteration of transcriptome profiling (RNA-seq) in CP5322-treated and non-treated cells. The drug was a herbal small molecular, which was designed as a HDAC inhibitor, called CP5322. TK1 was the group of CP5322-treated, and CK1 was the group of control. Methods: The mRNA profiles of drug-treated and non-treated cells were generated by next genenration sequencing, using Illumina platform. The clustering of the index-coded samples was performed on a cBot cluster generation system using HiSeq PE Cluster Kit v4-cBot-HS (Illumina) according to the manufacturer's instructions. After cluster generation, the libraries were sequenced on an Illumina platform and 150 bp paired-end reads were generated, which was called Raw Reads. And the low quality sequences and adaptor contamination were removed.Data processing was completed to obtain high-quality sequences (Clean Reads), and all subsequent analyses were based on Clean Reads. Results: Using the data analysis workflow, we mapped about 46 million sequence reads per sample to the human genome (h19) and identified 23 thousand transcripts in the drug-treated and non-treated cells. And the mapping rate was about 97%. RNA-seq data showed a significant alteration when the Kasumi-1 cells were treated by drug. Conclusions: The RNA-Seq data provided us a priori evidence for further research.

2020-03-01 | GSE142561 | GEO

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