Project description:The molecular basis of tumor recurrence remain poorly understood. Here, we performed RNA microarrays to study the genetic basis of the phenotypic differences between the primary and recurrent breast cancer cells.
Project description:Baseline gene expression for two primary and two recurrent tumor cell lines derived from MTB;TAN transgenic mice. Microarrays were performed in biological duplicate to determine differential gene expression between primary and recurrent tumor cell cohorts.
Project description:This SuperSeries is composed of the following subset Series: GSE39380: Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations (Copy number) GSE39381: Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations (Expression) Refer to individual Series
Project description:Glioblastoma (GBM) bears a dismal prognosis with rapid relapse following complete resection and radiochemotherapy. The involvement of microRNAs in tumor progression has been demonstrated in hepatoma, breast cancer, and prostate cancers. However, the microRNAs involved in modulating the progression and relapse of GBM are still unclear. Initially, we compared the miRNA expression profiles between primary and recurrent GBM tissues from the same patient in twelve independent cases. miRNA expression profiles between primary and recurrent GBM tissues from the same patient in twelve independent cases.
Project description:To understand to role of RIPK3 during tumor recurrence, we performed RNAseq to study the transcriptional response of mouse recurrent breast cancer cells to RIPK3 knockdown.
Project description:We performed RNAseq to study the transcriptional changes of human CAOV2 recurrent vs CAOV2 primary ovarian cancer cells to understand the genetic determinants of ferroptosis response