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Gene expression signatures of chemotherapy-induced neuropathy induced by vincristine

ABSTRACT: Gene expression signatures of chemotherapy-induced neuropathy induced by vincristine

PROVIDER: PRJNA514862 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8437150.fastq.gz	Fastqsanger.gz
	SRR8437160.fastq.gz	Fastqsanger.gz
	SRR8437170.fastq.gz	Fastqsanger.gz
	SRR8437151.fastq.gz	Fastqsanger.gz
	SRR8437161.fastq.gz	Fastqsanger.gz

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Gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin and oxaliplatin

Project description:Gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin and oxaliplatin

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Gene expression signatures of chemotherapy-induced neuropathy induced by vincristine

Project description:Vincristine, oxaliplatin, and cisplatin are commonly prescribed chemotherapeutic agents for the treatment of several cancer types. However, a main side-effect is chemotherapy-induced peripheral neuropathy (CIPN), which may lead to decreased quality of life, changes in chemotherapeutic treatment or even treatment cessation. Although painful symptoms associated with CIPN are faithfully recapitulated by mouse models, there is limited knowledge of how these drugs affect the expression of genes in peripheral sensory neurons. The present study carried out a transcriptomic analysis of dorsal root ganglia isolated from mice treated with vincristine, oxaliplatin, and cisplatin with a view to gain insight into the comparative pathophysiological mechanisms of CIPN. RNA-Seq using 75-nucleotide single end runs revealed 368, 295 and 256 differential expressed genes (DEGs) induced by treatment with vincristine, oxaliplatin and cisplatin, respectively. Although there were many similarities in DEGs between chemotherapeutic agents, only 5 genes were dysregulated in all groups. Cell type enrichment analysis (CTEA) and gene set enrichment analysis (GSEA) showed predominant effects on genes associated with the immune system after treatment with vincristine, while oxaliplatin treatment affected mainly neuronal genes. Treatment with cisplatin resulted in a mixed inflammatory and neuropathic gene expression signature. Only ‘regulation of transport’ and ‘response to external stimuli’ were gene ontology terms shared between all treatments. These results provide insight into the recruitment of innate and adaptive immune responses to DRG tissue and indicate enhanced neuro-inflammatory processes following administration of vincristine, oxaliplatin, and cisplatin. These gene expression signatures may provide insight into novel drug targets for treatment of CIPN.

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Gene expression signatures of chemotherapy-induced neuropathy induced by cisplatin and oxaliplatin

2019-06-01 | GSE125002 | GEO

Gene expression signatures of chemotherapy-induced neuropathy induced by cisplatin and oxaliplatin

Project description:Gene expression signatures of chemotherapy-induced neuropathy induced by cisplatin and oxaliplatin

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Gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin and oxaliplatin

Project description:This SuperSeries is composed of the SubSeries listed below.

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Lidocaine for Oxaliplatin-induced Neuropathy

Project description:Oxaliplatin-induced neuropathy is a major dose-limiting side effect in patients with colorectal cancer treated with the FOLFOX chemotherapy regimen. Hypersensitivity to cold is the sensory hallmark of oxaliplatin-induced neuropathy, and it can predict the development of long-term neuropathy. In this study, the investigators aim to determine whether intravenous lidocaine can prevent oxaliplatin-induced cold hypersensitivity.

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