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Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2/3 islands located in genomic euchromatin

ABSTRACT: Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2/3 islands located in genomic euchromatin

PROVIDER: PRJNA515827 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8454242_1.fastq.gz	Fastqsanger.gz
	SRR8454242_2.fastq.gz	Fastqsanger.gz
	SRR8454243_1.fastq.gz	Fastqsanger.gz
	SRR8454243_2.fastq.gz	Fastqsanger.gz
	SRR8454244_1.fastq.gz	Fastqsanger.gz

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Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin.

Project description:Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated with repetitive sequences enriched in PCH genomic regions. We investigated the 3D architecture of Drosophila melanogaster PCH domains and their spatial associations with the euchromatic genome by developing a novel analysis method that incorporates genome-wide Hi-C reads originating from PCH DNA. Combined with cytogenetic analysis, we reveal a hierarchical organization of the PCH domains into distinct "territories." Strikingly, H3K9me2-enriched regions embedded in the euchromatic genome show prevalent 3D interactions with the PCH domain. These spatial contacts require H3K9me2 enrichment, are likely mediated by liquid-liquid phase separation, and may influence organismal fitness. Our findings have important implications for how PCH architecture influences the function and evolution of both repetitive heterochromatin and the gene-rich euchromatin.

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Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2/3 islands located in genomic euchromatin

Project description:We aim to investigate the spatial contacts between heterochromatin domain and the euchromatic genome. We found that euchromatic transposable elements, which are usually associated with H3K9me2 enrichment, are in 3D contacts with the main heterochromatin domain

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Heterochromatic islands in euchromatin are in spatial contacts with the hierarchically organized heterochromatin domain

Project description:Heterochromatic islands in euchromatin are in spatial contacts with the hierarchically organized heterochromatin domain

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Chromatin architecture in hexaploid wheat is hierarchically organized around genome territories and transcription factories

Project description:Chromatin architecture in hexaploid wheat is hierarchically organized around genome territories and transcription factories

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Chromatin architecture in hexaploid wheat is hierarchically organized around genome territories and transcription factories (Wheat_ChIP)

Project description:Chromatin architecture in hexaploid wheat is hierarchically organized around genome territories and transcription factories (Wheat_ChIP)

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Chromatin architecture in hexaploid wheat is hierarchically organized around genome territories and transcription factories (Wheat_RNAseq)

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Chromatin architecture in hexaploid wheat is hierarchically organized around genome territories and transcription factories (Wheat_ATAC)

Project description:Chromatin architecture in hexaploid wheat is hierarchically organized around genome territories and transcription factories (Wheat_ATAC)

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ChIP-seq of Histone H3, H3K4me3 and H3K9me2 in the Sf9 cell line

Project description:Spodoptera frugiperda is a notorious agricultural pest in its caterpillar form. As most Lepidoptera, its genome is organized in 31 chromosomes with dispersed centromeres instead of a single one per chromosome. This property is called holocentrism and is found in several animal groups as well as some plants. In the best known monocentric species, the pericentromeric region is abundant in repeat elements and is usually constituted of a large heterochromatin block. Thus we wanted to address the localization of euchromatin and heterochromatin in Sf9 cell line by using 2 markers corresponding to a tri-methylation of H3 on the lysine 4 (H3K4me3) or di-methylation on lysine 9 (H3K9me2). ChIP-seq on Sf9 cells have been performed using specific antibodies and compared to an Input sample.

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Chromatin architecture in hexaploid wheat is hierarchically organized around genome territories and transcription factories (Rapeseed_Hi-C)

Project description:Chromatin architecture in hexaploid wheat is hierarchically organized around genome territories and transcription factories (Rapeseed_Hi-C)

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Chromatin architecture in hexaploid wheat is hierarchically organized around genome territories and transcription factories (Wheat_Hi-C)

Project description:Chromatin architecture in hexaploid wheat is hierarchically organized around genome territories and transcription factories (Wheat_Hi-C)

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