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The gene expression analysis of TDP knocked down MIN6 cells.

ABSTRACT: The gene expression analysis of TDP knocked down MIN6 cells.

PROVIDER: PRJNA516346 | ENA |

REPOSITORIES: ENA

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The gene expression analysis of TDP knocked down MIN6 cells.

Project description:TAR DNA-binding protein 43 kDa (TDP-43), encoded by TARDBP, is an RNA-binding protein, the nuclear depletion of which is the histopathological hallmark of amyotrophic lateral sclerosis (ALS). Here, we show that ALS subjects have reduced early-phase insulin secretion and that the nuclear localization of TDP-43 is lost in the islets of autopsied ALS pancreas. Loss of TDP-43 inhibits exocytosis, thereby reducing early-phase insulin secretion in a cultured β cell line (MIN6). Using microarray analysis, we identified the genes causing insulin impaired in TDP knocked down MIN6 cells.

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Gene expression data from Min6 cells grown in serum containing and serum free condtions following Hes3 knock down

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