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Gene expression data from human ovarian cancer cells treated with siRNAs targeting CPNE8 and BHLHE41

ABSTRACT: Gene expression data from human ovarian cancer cells treated with siRNAs targeting CPNE8 and BHLHE41

PROVIDER: PRJNA516706 | ENA |

REPOSITORIES: ENA

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Gene expression data from human ovarian cancer cells treated with siRNAs targeting CPNE8 and BHLHE41

Project description:To examine the role of CPNE8 and BHLHE41 in ovarian cancer cells, RMG1 cells were treated with siRNA targeting CPNE8 (siCPNE8 #A and #B) or control siRNA (siControl), and OVCAR3 cells were treated with siRNA targeting BHLHE41 (siBHLHE41 #A and #B) or control siRNA (siControl). Microarray analysis showed that CPNE8 and BHLHE41 are involved in cellular signaling pathways in ovarian cancer.

2019-08-23 | GSE125542 | GEO

Transcription profiling by array of embryonic chick retina treated with Hes5.3 siRNAs, Atoh7 siRNAs and non-targeting siRNAs.

Project description:Transcription profiling by array of embryonic chick retina treated with Hes5.3 siRNAs, Atoh7 siRNAs and non-targeting siRNAs.

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Transcription profiling by array of embryonic chick retina treated with Hes5.3 siRNAs, Atoh7 siRNAs and non-targeting siRNAs.

Project description:The microarray analysis was designed to test the effects of Hes5.3 siRNAs, Atoh7 siRNAs and non-targeting siRNAs on gene expression at the periphery of the expanding Hes5.3 domain in embryonic chick retina. For this microarray we collected retina samples 16 hours after electroporation to complete our previous analysis performed on samples collected 36 hours after RNA interference treatment (Chiodini et al., 2013).

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Gene expression data from human breast cancer MDA-MB-231 cells treated with siRNAs targeting long non-coding RNA TMPO-AS1

Project description:To examine the role of long non-coding RNA TMPO-AS1 in breast cancer, MDA-MB-231 cells were treated with siRNAs targeting TMPO-AS1 (siTMPO-AS1) or control siRNA (siControl). 3 samples

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Gene expression data from human breast cancer MCF-7 cells treated with siRNAs targeting long non-coding RNA TMPO-AS1

Project description:To examine the role of long non-coding RNA TMPO-AS1 in breast cancer, MCF-7 cells were treated with siRNAs targeting TMPO-AS1 (siTMPO-AS1) or control siRNA (siControl). TMPO-AS1 was shown to closely associate with estrogen signaling pathway.

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Gene expression data from human breast cancer MCF-7 cells treated with siRNAs targeting SCFD2

Project description:To examine the role of SCFD2 in breast cancer, MCF-7 cells were treated with siRNAs targeting SCFD2 (siSCFD2) or control siRNA (siControl). SCFD2 silencing represses expressions of anti-apoptotic genes which are positively associated with shorter relapse-free survival in ER-positive breast cancer patients. These results reveal the clinical and functional significance of SCFD2 and its targets in hormone-dependent breast cancer. SCFD2 may be applied to the cancer management as a promising diagnostic and therapeutic target.

2022-05-28 | GSE163553 | GEO

Gene expression data from human breast cancer MCF-7 cells treated with siRNAs targeting SCFD2

Project description:Gene expression data from human breast cancer MCF-7 cells treated with siRNAs targeting SCFD2

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TMT-MS of PCIF1 siRNAs treated RPE-1 cells

Project description:RPE-1 cells treated with the indicated siRNAs for 48 h were subjected to the tandem mass tag quantitative proteomics analysis.Carry out relative protein quantification analysis using tandem mass tag mass spectrometry in RPE-1 cells to investigate the mechanism underlying PCIF1 attenuates ciliation.

2024-03-21 | PXD044338 | Pride

Monocyte-derived macrophages (MDMs) treated with siRNA non-targeting control and pooled GAPLINC siRNAs

Project description:Monocyte-derived macrophages (MDMs) treated with siRNA non-targeting control and pooled GAPLINC siRNAs

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SAGE-Seq gene expression profiles of Hs578T, MCF7, and SUM159PT cells treated with STAT3 or non-targeting siRNAs, DMSO, or CXCR2, PTGIS, HAS1, PFKFB3, JAK, or NQO1 inhibitor

Project description:To investigate potential links between Stat3 transcriptional activity and other signaling pathways in breast cancer, we determined the gene expression profiles of three breast cancer cell lines treated with JAK, PTGIS, PFKFB3, CXCR2, HAS1, or NQO1 inhibitor (all of which decreased Stat3 transcriptional activity in Hs 578T cells except for the NQO1 inhibitor), inhibitor treatment vehicle alone (DMSO), STAT3 siRNAs, or non-targeting siRNAs. Using the resulting data, we identified a gene signature that was significantly regulated by STAT3 siRNAs and similarly affected by the JAK and at least 3 other inhibitors (or by 4 other inhibitors) but not by the NQO1 inhibitor in Hs 578T cells that was enriched in genes involved in development and correlated with shorter distant metastasis-free survival in primary lymph-node-negative invasive breast tumors. These results emphasize the central importance of Stat3 in CD44+/CD24- stem-cell-like breast cancer cells. This study includes SAGE-Seq libraries obtained using 27 samples that each underwent individual protocols. There are nine samples of each of three cell lines - Hs 578T, MCF7, and SUM159PT. The samples in each group were treated with either one of the six inhibitors, DMSO only (the background control for inhibitor-treated cells), STAT3 siRNAs, or non-targeting siRNAs (the background control for STAT3 siRNAs).

2011-09-08 | E-GEOD-22917 | biostudies-arrayexpress

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