Transcriptomic responses of human monocyte-derived dendritic cells to HIV and other innate stimuli
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ABSTRACT:
PROVIDER: PRJNA517651 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR8501720.fastq.gz | Fastqsanger.gz | |||
| SRR8501730.fastq.gz | Fastqsanger.gz | |||
| SRR8501740.fastq.gz | Fastqsanger.gz | |||
| SRR8501750.fastq.gz | Fastqsanger.gz | |||
| SRR8501760.fastq.gz | Fastqsanger.gz |
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Project description:HIV-1 Vpr protein is a multifunctional protein which perturbs human transcriptome and interacts with a number of cellular proteins. In this study, we have attempted to explore the efffects of Vpr on human transcriptome and have identified several genes which are involved in innate immune responses. We used the microarray analysis to elucidate the differnetail expression pattern of differnet genes in human dendritic cells infected with HIV-1 Vpr. As result we found that HIV-1 Vpr protein leads to the induction of various interferon stimualted genes (ISGs) in human monocyte derived dendritic cells.
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