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An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation

ABSTRACT: An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation

PROVIDER: PRJNA521635 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8555190_1.fastq.gz	Fastqsanger.gz
	SRR8555190_2.fastq.gz	Fastqsanger.gz
	SRR8555200_1.fastq.gz	Fastqsanger.gz
	SRR8555200_2.fastq.gz	Fastqsanger.gz
	SRR8555210_1.fastq.gz	Fastqsanger.gz

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An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation [RNA-seq]

Project description:An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation [RNA-seq]

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An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation [ChIP-seq]

Project description:An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation [ChIP-seq]

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An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation [ChIP-seq]

Project description:Upon activation, lymphocytes exit quiescence and undergo substantial increases in cell size and RNA content. A key regulator in this process is the Myc transcription factor, which is directly induced by activating signals and is required for multiple facets of cell activation, including metabolic reprogramming, chromatin decompaction, RNA and protein accumulation, cell growth and proliferation. However, how Myc activity impacts on those diverse cellular processes remains unclear. We addressed this issue in primary mouse B-cells, based on conditional deletion of the c-myc gene prior to LPS stimulation. Myc was rapidly induced, was recruited to virtually all active promoters and enhancers (a phenomenon known as invasion), but had no direct impact on global transcriptional activity. Instead, Myc contributed to the swift up- and down-regulation of several hundred genes, including many known regulators of the aforementioned cellular processes. Myc-activated promoters were enriched for E-box consensus motifs, bound Myc at the highest levels and showed enhanced RNA Polymerase II recruitment, the opposite being true at down-regulated loci. Remarkably, the Myc-dependent signature identified in activated B-cells was also enriched in Myc-driven B-cell lymphomas: hence, besides modulation of new cancer-specific programs, the oncogenic action of Myc may largely rely on sustained deregulation of its normal physiological targets.

2019-06-14 | GSE126339 | GEO

An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation [RNA-seq]

2019-06-14 | GSE126338 | GEO

An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-06-14 | GSE126340 | GEO

Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis

Project description:Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis

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Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis [I]

Project description:Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis [I]

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Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis [II]

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MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis

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Enhanced Salicylic Acid Biosynthesis Is Involved in Heterosis for Bacterial Defense in Arabidopsis

Project description:We provide evidence that heterosis for bacterial defense exists in hybrids crossed between some Arabidopsis accessions. Comparison of transcriptomes between hybrids exhibiting heterosis for disease resistance and their parents after inoculation with Pst DC3000 revealed that several key genes involved in salicylic acid (SA) biosynthesis were significantly up-regulated in hybrids. Consistently, in response to bacterial infection, more SA [both free SA and SA glycoside (SAG)] accumulated in hybrids compared with both parents. In addition, heterosis for bacterial defense was significantly compromised in hybrids of pad4 mutants in which the SA biosynthesis pathway was blocked. Moreover, we further revealed that increased histone H3 acetylation of the key genes involved in the SA biosynthesis pathway correlated with their up-regulated expression in hybrids. Around 30 inoculated leaves from Arabidopsis accessions Col-0 and Sei-0 as well as their reciprocal hybrids Fcs and Fsc, which showed best-parent heterosis for bacterial defense were pooled in each sample for mRNA Seq using HiSeq 2000 sequencing system (Illumina)

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