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Gene expression analysis of a subcutaneous MV4 11 tumor treated with curaxin CBL0137.

ABSTRACT: Gene expression analysis of a subcutaneous MV4 11 tumor treated with curaxin CBL0137.

PROVIDER: PRJNA521944 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8566362_1.fastq.gz	Fastqsanger.gz
	SRR8566362_2.fastq.gz	Fastqsanger.gz
	SRR8566363_1.fastq.gz	Fastqsanger.gz
	SRR8566363_2.fastq.gz	Fastqsanger.gz
	SRR8566364_1.fastq.gz	Fastqsanger.gz

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Comparation the mRNA Expression Profile of the MV4-11 Sorafenib Resistant Cells and the Parental Cells

Project description:Our gene set analysis of MV4-11-R versus MV4-11 indicated decreased depolarization of mitochondria and mitochondrial membrane, mitochondrial dysfunction and anti-apoptosis as other top ranked molecular or cellular functions of differential gene sets. expression of most genes encoding glycolytic enzymes was up-regulated in MV4-11-R cells we revealed a metabolic alteration in sorafenib-resistant cell lines with mitochondrial respiration deficiency, leading to substantial decrease of mitochondria-derived ATP generation and a significant increase in glycolytic activity to maintain sufficient ATP production. Our study revealed a metabolic signature of sorafenib resistance and indicated that increase of glycolytic activity including upregulation of major glycolytic enzymes may be viewed as a marker for early detection of sorafenib resistance in AML patients with FLT3/ITD mutation and glycolytic inhibitors warrant further investigation as alternative therapeutic agents for sorafenib-resistant cells Sorafenib resistant cells MV411-R VS. parental MV4-11 cells. Biological replicates: 3 control replicates, 3 treated replicates.

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