Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The long non-coding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration

ABSTRACT: The long non-coding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration

PROVIDER: PRJNA523391 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8598000_1.fastq.gz	Fastqsanger.gz
	SRR8598000_2.fastq.gz	Fastqsanger.gz
	SRR8598010_1.fastq.gz	Fastqsanger.gz
	SRR8598010_2.fastq.gz	Fastqsanger.gz
	SRR8598020_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 72

Similar Datasets

The long non-coding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration (array)

Project description:The long non-coding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration (array)

| PRJNA523389 | ENA

The long non-coding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration (RNA-Seq)

Project description:The long non-coding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration (RNA-Seq)

| PRJNA523394 | ENA

The long non-coding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration (RNA-Seq)

Project description:EpCAM+ lung epithelial cells were isolated by magnetic bead sorting from either wild-type animals 10-12 weeks of age, or with the genotypes Falcor-/-, Foxa2+/-, or Double-Het (Falcor+/-;Foxa2+/-) animals

2022-01-31 | GSE126817 | GEO

The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration.

Project description:Transcription factors (TFs) are dosage-sensitive master regulators of gene expression, with haploinsufficiency frequently leading to life-threatening disease. Numerous mechanisms have evolved to tightly regulate the expression and activity of TFs at the transcriptional, translational, and posttranslational levels. A subset of long noncoding RNAs (lncRNAs) is spatially correlated with transcription factors in the genome, but the regulatory relationship between these lncRNAs and their neighboring TFs is unclear. We identified a regulatory feedback loop between the TF Foxa2 and a downstream lncRNA, Falcor (Foxa2-adjacent long noncoding RNA). Foxa2 directly represses Falcor expression by binding to its promoter, while Falcor functions in cis to positively regulate the expression of Foxa2. In the lung, loss of Falcor is sufficient to lead to chronic inflammatory changes and defective repair after airway epithelial injury. Moreover, disruption of the Falcor-Foxa2 regulatory feedback loop leads to altered cell adhesion and migration, in turn resulting in chronic peribronchial airway inflammation and goblet cell metaplasia. These data reveal that the lncRNA Falcor functions within a regulatory feedback loop to fine-tune the expression of Foxa2, maintain airway epithelial homeostasis, and promote regeneration.

| S-EPMC6546060 | biostudies-literature

The long non-coding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-01-31 | GSE126818 | GEO

The long non-coding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration (array)

Project description:One month following airway injury with naphthalene (275mg/kg IP x1 in corn oil), total RNA was isolated from one lobe of the right lung (whole lung) from either Falcor-/- (null) or injured wild-type control mice.

2022-01-31 | GSE126816 | GEO

AR cooperates with SMAD4 to maintain muscle homeostasis

Project description:AR cooperates with SMAD4 to maintain muscle homeostasis

| PRJNA771642 | ENA

MrgprD-expressing neurons maintain cutaneous mast cell homeostasis

Project description:MrgprD-expressing neurons maintain cutaneous mast cell homeostasis

| PRJNA600963 | ENA

GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

Project description:GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

| PRJNA663319 | ENA

Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function (Insm1, Neurod1 and Foxa2 ChipSeq data from pancreatic beta cell)

Project description:Genome-wide Insm1 binding sites analysis revealed an overrepresentation of sequences predicted to bind bHLH and/or forkhead factors, and further analyses demonstrated that most Insm1 sites in the genome are co-occupied by Neurod1 and Foxa2. Binding regions co-occupied by all three factors but not single Insm1 sites explained a significant fraction of gene expression changes in Insm1 mutant β-cells. Together, our data provide evidence that an Insm1, Neurod1 and Foxa2 network maintains a mature gene expression program in β-cells. 6 samples include, replicates of Insm1 and Foxa2, IgG pull down as a control

2015-03-31 | E-GEOD-54046 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data