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TNFα and LTβ stimulated UM-SCC 46 gene expression [LTB]

ABSTRACT: TNFα and LTβ stimulated UM-SCC 46 gene expression [LTB]

PROVIDER: PRJNA523625 | ENA |

REPOSITORIES: ENA

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TNFα and LTβ stimulated UM-SCC 46 gene expression [LTB]

Project description:To investigate the regulatory mechanisms and targets of the activation of NF-kappaB and inflammatory pathways, we treated HPV(-) head and neck cancer line UM-SCC 46 cells with TNFα and LTβ at different time points, and compared the gene expression by microarray. TNFα uniquely induced 172 genes, LTβ specifically induced 202 genes, while 155 genes were induced by both ligands. Total RNA samples were isolated from UM-SCC 46 cells after TNFα or LTβ treatment at different time points, and the gene expression were compared with untreated cell controls.

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Project description:To investigate the regulatory mechanisms and targets of the activation of NF-kB and inflammatory pathways, we treated HPV(-) head and neck cancer line UM-SCC 46 cells with TNFα and LTβ at different time points, and compared the gene expression by microarray. TNFα uniquely induced 172 genes, LTβ specifically induced 202 genes, while 155 genes were induced by both ligands. Total RNA samples were isolated from UM-SCC 46 cells after TNFα or LTβ treatment at different time points, and the gene expression were compared with untreated cell controls.

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TNFa and LTB stimulated UM-SCC 46 gene expression

Project description:TNFa and LTB stimulated UM-SCC 46 gene expression

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TNFa and LTB stimulated UM-SCC 46 gene expression

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