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Comparative transcriptome profiling of Chinese tongue sole in immune response against Vibrio harveyi infection

ABSTRACT: Comparative transcriptome profiling of Chinese tongue sole in immune response against Vibrio harveyi infection

PROVIDER: PRJNA524115 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8618350_1.fastq.gz	Fastqsanger.gz
	SRR8618350_2.fastq.gz	Fastqsanger.gz
	SRR8618351_1.fastq.gz	Fastqsanger.gz
	SRR8618351_2.fastq.gz	Fastqsanger.gz
	SRR8618342_1.fastq.gz	Fastqsanger.gz

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Comparative transcriptome profiling of Chinese tongue sole in immune response against Vibrio harveyi infection

Project description:Vibrio harveyi is a major bacterial pathogen that can cause fatal vibriosis in Chinese tongue sole (Cynoglossus semilaevis). To comprehend the molecular mechanisms of C. semilaevis host response against V. harveyi infection, we performed transcriptome (RNA-seq) analysis of C. semilaevis from resistant family and susceptible family.

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Comparative transcriptome profiling of immune response against Vibrio harveyi infection in Chinese tongue sole.

Project description:Vibrio harveyi is a major bacterial pathogen that causes fatal vibriosis in Chinese tongue sole (Cynoglossus semilaevis), resulting in massive mortality in the farming industry. However, the molecular mechanisms of C. semilaevis response to V. harveyi infection are poorly understood. Here, we performed transcriptomic analysis of C. semilaevis, comparing resistant and susceptible families in response to V. harveyi challenge (CsRC and CsSC) and control conditions (CsRU and CsSU). RNA libraries were constructed using 12 RNA samples isolated from three biological replicates of the four groups. We performed transcriptome sequencing on an Illumina HiSeq platform, and generating a total of 1,095 million paired-end reads, with the number of clean reads per library ranging from 75.27?M to 99.97?M. Through pairwise comparisons among the four groups, we identified 713 genes exhibiting significant differences at the transcript level. Furthermore, the expression levels were validated by real-time qPCR. Our results provide a valuable resource and new insights into the immune response to V. harveyi infection.

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Identify and characterize the circular RNAs expressed in in the half-smooth tongue sole (Cynoglossus semilaevis)

Project description:Half-smooth tongue sole (Cynoglossus semilaevis) is a commercially valuable flatfish, ranking among the most valuable fishes in the coastal areas of China. It has an asymmetric body shape with lateralization of the eyes to the same side during metamorphosis as same as the other flatfish species. However, little is known about the function and profile of circRNAs in the half-smooth tongue sole. In this study,a total of 2730 circRNAs were identified from in the fish by deep RNA-sequencing technique.

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Project description:Vibrio spp. are major pathogens responsible for mortality and disease in various marine aquaculture organisms. Effective disease control and genetic breeding strategies rely heavily on understanding host vibriosis resistance mechanisms. The Chinese tongue sole (Cynoglossus semilaevis) is economically vital but suffers from substantial mortalities due to vibriosis. Through continuous selective breeding, we have successfully obtained vibriosis-resistant families of this species. In this study, we conducted RNA-seq analysis on three organs, including liver, spleen and intestine from selected resistant and susceptible tongue soles. Additionally, we integrated these data with our previously published RNA-seq datasets of skin and gill, enabling the construction of organ-specific transcriptional profiles and a comprehensive gene co-expression network elucidating the differences in vibriosis resistance. Furthermore, we identified 12 modules with organ-specific functional implications. Overall, our findings provide a valuable resource for investigating the molecular basis of vibriosis resistance in fish, offering insights into target genes and pathways essential for molecular selection and genetic manipulation to enhance vibriosis resistance in fish breeding programs.

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