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RNA-sequencing analysis of colon tissue in a murine EAE model after dietary tryptophan deprivation.

ABSTRACT: RNA-sequencing analysis of colon tissue in a murine EAE model after dietary tryptophan deprivation.

PROVIDER: PRJNA524321 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8632880.fastq.gz	Fastqsanger.gz
	SRR8632890.fastq.gz	Fastqsanger.gz
	SRR8632881.fastq.gz	Fastqsanger.gz
	SRR8632891.fastq.gz	Fastqsanger.gz
	SRR8632882.fastq.gz	Fastqsanger.gz

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RNA-sequencing analysis of colon tissue in a murine EAE model after dietary tryptophan deprivation.

Project description:In the experimental autoimmune encephalomyelitis (EAE) model we found that omission of the essential amino acid tryptophan (trp) abrogates central nervous system (CNS) autoimmunity. Impaired encephalitogenic T responses were accompanied by an inflammatory response in the colonic mucosa, as well as a profound shift in the gut microbiota. Here, we performed transcriptional profiling of colon tissue by RNA-sequencing 14 days after disease induction in mice that received a trp-free diet or a matched control group to identify key networks that drive this immunosuppressive effect.

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