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Small RNA-seq During Acute Maximal Exercise Reveal RNAs Involved in Vascular Inflammation and Cardiometabolic Health

ABSTRACT: Small RNA-seq During Acute Maximal Exercise Reveal RNAs Involved in Vascular Inflammation and Cardiometabolic Health

PROVIDER: PRJNA524404 | ENA |

REPOSITORIES: ENA

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Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health

Project description:Exercise improves cardiometabolic and vascular function, though mechanisms remain unclear. Our objective was to demonstrate the diversity of circulating extracellular RNA (ex-RNA) release during acute exercise in humans and its relevance to exercise-mediated benefits on vascular inflammation. We performed plasma small RNA sequencing (RNA-seq) in 26 individuals undergoing symptom-limited maximal treadmill exercise, with replication of our top candidate miRNA in a separate cohort of 59 individuals undergoing bicycle ergometry. We found changes in miRNAs and other ex-RNAs with exercise (e.g., y-RNAs, t-RNAs) implicated in cardiovascular disease. In two independent cohorts of acute maximal exercise, we identified miR-181b-5p as a key ex-RNA increased in plasma after exercise, with validation in a separate cohort. In a mouse model of acute exercise, we found significant increases in miR-181b-5p expression in skeletal muscle after acute exercise in young (but not older) mice. Previous work revealed a strong role for miR-181b-5p in vascular inflammation in obesity, insulin resistance, sepsis, and cardiovascular disease. Circulating ex-RNAs altered in plasma after acute exercise target pathways involved in inflammation, including miR-181b-5p. Further investigation into the role of known (e.g., miRNA) and novel (e.g., y-RNAs) is warranted to uncover new mechanisms of vascular inflammation on exercise-mediated benefits on health.

2018-10-27 | GSE121874 | GEO

Small RNA-seq During Acute Maximal Exercise Reveal RNAs Involved in Vascular Inflammation and Cardiometabolic Health

Project description:Small RNA-seq During Acute Maximal Exercise Reveal RNAs Involved in Vascular Inflammation and Cardiometabolic Health

| PRJNA524405 | ENA

Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health

Project description:Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health

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Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health

Project description:Circulating ex-RNAs altered in plasma after acute exercise target pathways involved in inflammation, including miR-181b-5p.

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Project description:Hypoxic conditions and maximal exercise provide related but distinct energetic stresses for muscle tissue and induce different adaptations in skeletal muscle in mammals. High swim performance fish, including Danio Rerio (Zebrafish), are well-able to tolerate both hypoxia and fast swimming. Expression profiling was performed using microarrays to compare and contrast the adaptations to sustained hypoxia and repeated near maximal exercise in skeletal muscle of adult wild-type Zebrafish.

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Project description:Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health

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Muscle Transcriptome Profile of Resistance Exercise is Augmented by Aerobic Exercise

Project description:10 male subjects performed ~45 min one-legged cycling and 4 x 7 maximal concentric-eccentric knee extensions for each leg 15 min later. Thus, one limb performed aerobic and resistance exercise (AE+RE), while the opposing leg did resistance exercise only (RE). Biopsies were obtained from m. vastus lateralis of each leg 3 h after the resistance exercise bout. Gene expression analysis was carried out on the Affymetrix HuGene-2.1-st platform.

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2019-12-31 | GSE116917 | GEO

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