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Gene expression changes in tumor following ADH-503 treatment

ABSTRACT: Gene expression changes in tumor following ADH-503 treatment

PROVIDER: PRJNA524652 | ENA |

REPOSITORIES: ENA

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Gene expression changes in tumor following ADH-503 treatment

Project description:To understand the effect of ADH-503, we have employed microarray expression profiling to identify genes that change at different times 48hrs and 10 days after treatment initiation. CD11b/18 (alphaMbeta2), an integrin molecule is highly expressed on all myeloid cells and plays an important role in transendothelial migration and functional changes in these cells. Here we demonstrate that a small molecule agonist of CD11b, ADH-503 was associated reprograming tumor immunity by promoting anti-tumor immune cell populations by enhancing antigen presentation by macrophages and cDCs and together these changes resulted in stabilization of tumor growth and improvement in overall survival.

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