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Single cell RNA-seq identifies cell diversity in embryonic salivary glands [Single cell RNA-seq]

ABSTRACT: Single cell RNA-seq identifies cell diversity in embryonic salivary glands [Single cell RNA-seq]

PROVIDER: PRJNA524860 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8646740.fastq.gz	Fastqsanger.gz
	SRR8646741.fastq.gz	Fastqsanger.gz
	SRR8646742.fastq.gz	Fastqsanger.gz
	SRR8646743.fastq.gz	Fastqsanger.gz
	SRR8646734.fastq.gz	Fastqsanger.gz

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Single nucleus RNA-sequencing for 3 normal salivary glands

Project description:Salivary glands are composed of several types of cells, and each cell type is predicted to be involved in the carcinogenesis of different types of cancers. In this study, we performed single nucleus RNA-seq on 3 human salivary gland samples to clarify the gene expression profile of each complex cellular component of the salivary glands.

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Single cell RNA-seq identifies cell diversity in embryonic salivary glands [Single cell RNA-seq]

Project description:Our single-cell and bulk transcriptome analyses revealed striking molecular heterogeneity in the mesenchymal cells of embryonic submandibular and parotid salivary glands during bud initiation, including distinct mesodermal and neural crest-derived molecular signatures that foreshadow later functions.

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Single cell RNA-seq identifies cell diversity in embryonic salivary glands [Bulk RNA-seq]

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Single cell RNA-seq identifies cell diversity in embryonic salivary glands

Project description:Single cell RNA-seq identifies cell diversity in embryonic salivary glands

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Single cell RNA-seq identifies cell diversity in embryonic salivary glands [Bulk RNA-seq]

Project description:Single cell RNA-seq identifies cell diversity in embryonic salivary glands [Bulk RNA-seq]

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Single cell RNA-sequencing of epithelial cells, endothelial cells and macrophages from mouse submandibular salivary glands

Project description:The salivary glands often become damaged in individuals receiving radiotherapy for head and neck cancer, resulting in chronic dry mouth. This leads to detrimental effects on their health and quality of life, for which there is no regenerative therapy. Macrophages are the predominant immune cell in the salivary glands and are attractive therapeutic targets due to their unrivalled capacity to drive tissue repair. Yet, the nature and role of macrophages in salivary gland homeostasis, and how they may contribute to tissue repair following injury is not well understood. Here, using scRNAseq we profile the transcriptomes of adult mouse salivary gland macrophages at steady state (D0) and at days 3 and 28 after targeted irradiation injury to define the transcriptional profiles of macrophages during homeostasis, acute injury and regeneration. We sorted epithelial cells (CD326+), endothelial cells (CD31+) and macrophages (CD45+CD11b+F4/80+) and sequenced their transcriptomes using 10x Genomics Single Cell 3' (v3.1). For each sample equal numbers of cells from 2 mice were pooled.

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RNA Seq Profiling of Murine Salivary Glands in the Presence or Absence of Active MCMV Infection

Project description:Recent work indicates that salivary glands are able to constitutively recruit CD8+ T cells and retain them as tissue resident memory T cells (TRM), independently of local infection, inflammation or antigen. To understand the mechanisms supporting T cell recruitment to the salivary gland, we compared T cell migration to the salivary gland in mice infected or not with murine cytomegalovirus (MCMV), a herpesvirus that infects the salivary gland and promotes the accumulation of salivary gland TRM. We found that acute MCMV infection increased rapid T cell recruitment to the salivary gland, but that equal numbers of activated CD8+ 44 T cells eventually accumulated in both infected and uninfected glands. T cell recruitment to uninfected salivary glands depended on chemokines and the integrin α4. Several chemokines were expressed in the salivary glands of both infected and uninfected mice and many of these could promote the migration of MCMV-specific T cells in vitro. MCMV infection increased expression of chemokines that interact with the receptors CXCR3 and CCR5, but neither receptor was needed for T cell recruitment to the salivary gland during MCMV infection. Unexpectedly however, the chemokine receptor CXCR3 was critical for T cell accumulation in uninfected salivary glands. Together, these data suggest that CXCR3 and the integrin α4 mediate T cell recruitment to uninfected salivary glands, but that redundant mechanisms mediate T cell recruitment after MCMV infection.

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Single cell RNA sequencing from organoid stroma derived from E16 salivary glands.

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Single-cell transcriptome profiling of the branching epithelium of mouse salivary glands

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