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RNA-sequencing and bioinformatics analysis of long non-coding RNAs and mRNAs in the prefrontal cortex of mice following repeated social defeat stress

ABSTRACT: RNA-sequencing and bioinformatics analysis of long non-coding RNAs and mRNAs in the prefrontal cortex of mice following repeated social defeat stress

PROVIDER: PRJNA525440 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8667221_1.fastq.gz	Fastqsanger.gz
	SRR8667221_2.fastq.gz	Fastqsanger.gz
	SRR8667222_1.fastq.gz	Fastqsanger.gz
	SRR8667222_2.fastq.gz	Fastqsanger.gz
	SRR8667223_1.fastq.gz	Fastqsanger.gz

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Project description:This study tested the effects of repeated social defeat (RSD) on gene expression in peripheral blood mononuclear cells (PBMC), and examined the extent to which these effects were abrogated by depletion of CD11b+ cells (monocytes). Study Type: Risk prediction Gene expression profiling was carried out on peripheral blood mononuclear cell (PBMC) mRNA samples collected from 18 mice randomized to either 6 cycles of repeated social defeat (RSD, n=9) or to home cage control (HCC, n=9) conditions. PBMC samples were pooled into 3 groups of n=3 samples in each condition, and Illumina Mouse Ref-8 BeadArray assays were performed on approximately 1 million total PBMC and 1 million PBMC from which CD11b+ cells were immunomagnetically depleted by MACS. The primary research questions are 1) whether expression of pro-inflammatory genes is altered by RSD, and 2) whether depletion of CD11b+ cells (monocytes) abrogates these effects.

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Microglial RNA-sequencing after stress-sensitization by repeated social defeat

Project description:Stress is associated with an increased prevalence of anxiety and depression. Repeated social defeat (RSD) stress in mice increases the release of monocytes from the bone marrow that are recruited to the brain by microglia. These monocytes enhance inflammatory signaling and augment anxiety. Moreover, RSD promotes stress sensitization, in which exposure to acute stress 24 days after cessation of RSD causes anxiety recurrence. The purpose of this study was to determine whether microglia were critical to stress sensitization and exhibited altered gene expression 24 days after RSD.

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Effect of propranolol on differential gene expression in peripheral blood monocytes from mice subject to repeated social defeat

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Effect of propranolol on differential gene expression in peripheral blood monocytes from mice subject to repeated social defeat

Project description:This study tested the effects of repeated social defeat (RSD) on gene expression in peripheral blood monocytes and examined the extent to which these effects were abrogated by the beta-adrenergic antagonist propranolol. Study Type: Risk prediction Gene expression profiling was carried out on peripheral blood monocyte mRNA samples collected from 36 mice randomized to either 6 cycles of repeated social defeat (RSD, n=18) or to parallel home cage control (HCC, n=18) conditions. Within each condition (RSD vs HCC), 9 animals were treated with the beta-adrenergic antagonist propranolol and 9 were treated with an equivalent volume of vehicle. After 6 cycles of RSD or parallel HCC, blood samples were pooled into groups of n=3 samples in each condition, and Illumina Mouse Ref-8 BeadArray assays were performed on RNA from approximately 1 million CD11b+ peripheral blood mononuclear cells (i.e., monocytes) which were immunomagnetically isolated by MACS. The primary research questions are 1) whether expression of pro-inflammatory genes is altered by RSD, and 2) whether treatment with propranolol abrogates these effects.

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Microglial RNA-sequencing after stress-sensitization by repeated social defeat

Project description:Microglial RNA-sequencing after stress-sensitization by repeated social defeat

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Gene expression profile at single cell level of splenocytes from wild-type and S100a9 knock-out mice ± repeated social defeat stress

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