Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tox4 Modulates Cell Fate Reprogramming

ABSTRACT: Tox4 Modulates Cell Fate Reprogramming

PROVIDER: PRJNA525830 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8689890.fastq.gz	Fastqsanger.gz
	SRR8689891.fastq.gz	Fastqsanger.gz
	SRR8689892.fastq.gz	Fastqsanger.gz
	SRR8689893.fastq.gz	Fastqsanger.gz
	SRR8689886.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Tox4 Modulates Cell Fate Reprogramming

Project description:Tox4 Modulates Cell Fate Reprogramming

| PRJNA525831 | ENA

Tox4 Modulates Cell Fate Reprogramming

Project description:Reprogramming to induced pluripotency induces the switch of somatic cell identity to induced pluripotent stem cells (iPSCs). However, the mediators and mechanisms of reprogramming remain largely unclear. To elucidate the mediators and mechanisms of reprogramming, we used a siRNA mediated knockdown approach for selected candidate genes during the conversion of somatic cells into iPSCs. We identified Tox4 as a novel factor that modulates cell fate, using reprogramming efficiency towards iPSCs as an assay. We found that Tox4 is needed early in reprogramming to efficiently generate early reprogramming intermediates, irrespective of reprogramming conditions used. Tox4 enables proper exogenous reprogramming factor expression and the closing and opening of putative somatic and pluripotency enhancers early during reprogramming, respectively. We show that TOX4 protein assembles into a high molecular form. Moreover, Tox4 is also required for the efficient conversion of fibroblasts towards the neuronal fate, suggesting a broader role of Tox4 in modulating cell fate. Our study reveals Tox4 as a novel transcriptional modulator of cell fate that mediates reprogramming from the somatic state to the pluripotent and neuronal fate.

2019-09-19 | GSE127932 | GEO

Tox4 Modulates Cell Fate Reprogramming

2019-09-19 | GSE127930 | GEO

Tox4 Modulates Cell Fate Reprogramming to iPS Cells and Direct Reprogramming

Project description:Tox4 Modulates Cell Fate Reprogramming to iPS Cells and Direct Reprogramming

| PRJNA525829 | ENA

Tox4 modulates cell fate reprogramming.

Project description:Reprogramming to induced pluripotency induces the switch of somatic cell identity to induced pluripotent stem cells (iPSCs). However, the mediators and mechanisms of reprogramming remain largely unclear. To elucidate the mediators and mechanisms of reprogramming, we used a siRNA-mediated knockdown approach for selected candidate genes during the conversion of somatic cells into iPSCs. We identified Tox4 as a novel factor that modulates cell fate through an assay that determined the efficiency of iPSC reprogramming. We found that Tox4 is needed early in reprogramming to efficiently generate early reprogramming intermediates, irrespective of the reprogramming conditions used. Tox4 enables proper exogenous reprogramming factor expression, and the closing and opening of putative somatic and pluripotency enhancers early during reprogramming, respectively. We show that the TOX4 protein assembles into a high molecular form. Moreover, Tox4 is also required for the efficient conversion of fibroblasts towards the neuronal fate, suggesting a broader role of Tox4 in modulating cell fate. Our study reveals Tox4 as a novel transcriptional modulator of cell fate that mediates reprogramming from the somatic state to the pluripotent and neuronal fate.This article has an associated First Person interview with the first author of the paper.

| S-EPMC6826012 | biostudies-literature

Serpina3 modulates neuronal cell fate determination (scRNA sequencing)

Project description:Serpina3 modulates neuronal cell fate determination (scRNA sequencing)

| PRJNA694621 | ENA

Cell Fate Control by Engineered Chromatin Regulator

Project description:MS analysis to provide insights into proteins bound to engineered cell fate regulator NanogBiD during somatic cell reprogramming

2023-10-09 | PXD046008 |

Tox4 Modulates Cell Fate Reprogramming to iPS Cells and Direct Reprogramming

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-09-19 | GSE127933 | GEO

Metabolic activity affects RPE fate during cell reprogramming

Project description:Metabolic activity affects RPE fate during cell reprogramming

| PRJNA866108 | ENA

SRRM2 splicing factor modulates cell fate in early development

Project description:SRRM2 splicing factor modulates cell fate in early development

| PRJNA1018485 | ENA