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Expression data from BEAS-2B cells II

ABSTRACT: Expression data from BEAS-2B cells II

PROVIDER: PRJNA525876 | ENA |

REPOSITORIES: ENA

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high-throughput sequencing of circRNAs in T-BEAS-2B cells and C-BEAS-2B cells

Project description:We report the differential expression of circRNAs between T-BEAS-2B cells (cadmium-transformed BEAS-2B cells) and C-BEAS-2B cells (passage-matched control BEAS-2B cells) by high-throughput sequencing. T-BEAS-2B cells are BEAS-2B cells transformed by cadmium at 2.0 μM for twenty weeks, and C-BEAS-2B cells are their passage-matched control. RNAs were sequenced on Illumina HiSeq Xten platform in triplicates, and expressions of circRNAs were calculated by TPM (transcripts per kilobase of exon model per million mapped reads). Clean data per sample exceeds 10 GB. We find 235 significantly up-regulated circRNAs and 271 significantly down-regulated circRNAs in T-BEAS-2B cells relative to C-BEAS-2B cells. Our work provides clues and evidence for exploring the mechanism of circRNAs in cadmium carcinogenesis.

2024-01-26 | GSE165549 | GEO

Expression data from BEAS-2B cells II

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Expression data from BEAS-2B cells

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Silica-exposed BEAS-2B epithelial cells

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Expression data in BEAS-2B cells and HCT116 cells incubated with copper(II) for different times

Project description:Expression data in BEAS-2B cells and HCT116 cells incubated with copper(II) for different times

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Expression data in BEAS-2B cells and HCT116 cells incubated with copper(II) for different times

Project description:Copper induced stress is known to involve an enhanced oxidant production. This event could be accompanied by an antioxidant response. However, additional processes transcriptionally regulated might participate in the protective response against the metal ions. We used microarrays to detail the global programme of gene expression due to the copper overload and outline the cell processes mostly involved in the toxicity of the metal ions in two cell lines, BEAS-2B cells and HCT116 cells.

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