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The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity: RNA-seq analysis of the K5-Vgll3 transgenic mouse model of cutaneous and systemic lupus

ABSTRACT: The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity: RNA-seq analysis of the K5-Vgll3 transgenic mouse model of cutaneous and systemic lupus

PROVIDER: PRJNA527783 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8742800.fastq.gz	Fastqsanger.gz
	SRR8742810.fastq.gz	Fastqsanger.gz
	SRR8742820.fastq.gz	Fastqsanger.gz
	SRR8742830.fastq.gz	Fastqsanger.gz
	SRR8742840.fastq.gz	Fastqsanger.gz

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The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity: RNA-seq analysis of the K5-Vgll3 transgenic mouse model of cutaneous and systemic lupus

Project description:RNA-seq analysis of nonlesional skin, whole blood, and cultured primary keratinocytes of wild-type and autoimmunity-prone K5-Vgll3 mice, which overexpress the female-biased transcription cofactor VGLL3 in the epidermis and develop a progressive lupus-like rash and systemic autoimmune disease with features of systemic lupus erythematosus. These skin and blood data demonstrate that skin-directed overexpression of VGLL3 results in gene expression changes strikingly similar to those seen in skin and blood of patients with cutaneous and systemic lupus, respectively.

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