Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Distinct contributions of KAT2A histone acetyl-transferase complexes to human erythropoiesis

ABSTRACT: Distinct contributions of KAT2A histone acetyl-transferase complexes to human erythropoiesis

PROVIDER: PRJNA527967 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8749830.fastq.gz	Fastqsanger.gz
	SRR8749831.fastq.gz	Fastqsanger.gz
	SRR8749832.fastq.gz	Fastqsanger.gz
	SRR8749833.fastq.gz	Fastqsanger.gz
	SRR8749834.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Distinct contributions of KAT2A histone acetyl-transferase complexes to human erythropoiesis

Project description:KAT2A is a histone acetyl-transferase involved in stabilization of transcriptional activity through acetylation of lysine residue 9 of Histone 3. Mouse knockout models suggest that Kat2a is dispensable for haematopoietic stem and progenitor cell activity, despite a central role in survival and maintenance of Acute Myekoid Leukaemia cells through block of differentiation. Herein, we investigate KAT2A activity in human cord blood haematopoiesis and identify a specific requirement in the establishment of the erythroid lineage. KAT2A is required for specification and survival of Erythroid-Megakaryocytic progenitors, with regulation of expression of the erythropoietin receptor (EPOR) gene, which participates in lineage commitment, as well as of later effector genes in the platelet and erythroid lineages. Early and late lineage roles can be distinctly attributed to the ATAC and SAGA complexes in which context KAT2A exerts its activity. ATAC is active earlier in erythroid lineage development and mediates MEP specification from HSC, whilst SAGA activity is required post-commitment, including in expression of haemoglobin genes. We thus position KAT2A as a novel regulator of human erythropoiesis and separate early and later effects in lineage development with complex specificity. This has implications for putative therapeutic targeting of KAT2A complexes in leukaemia.

2021-09-28 | GSE128512 | GEO

Distinct contributions of KAT2A histone acetyl-transferase complexes to human erythropoiesis [RNA-seq]

2021-09-28 | GSE128902 | GEO

Distinct contributions of KAT2A histone acetyl-transferase complexes to human erythropoiesis [RNA-seq]

Project description:Distinct contributions of KAT2A histone acetyl-transferase complexes to human erythropoiesis [RNA-seq]

| PRJNA529250 | ENA

MOF acetyl transferase regulates transcription and respiration in mitochondria

Project description:MOF acetyl transferase regulates transcription and respiration in mitochondria

| PRJNA311550 | ENA

Histone acetyl transferase (HAT) and APSES TF of Aspergillus fumigatus

Project description:Histone acetyl transferase (HAT) and APSES TF of Aspergillus fumigatus

| PRJNA757944 | ENA

ACSS2-coupled KAT2A regulates histone H3 lactylation in gene promoter regions and gene expression

Project description:We report EGFR activation induces ERK-mediated S267 phosphorylation of acetyl-CoA synthetase 2 (ACSS2) and its subsequent nuclear translocation and complex formation with lysine acetyltransferase 2A (KAT2A).Consequently, KAT2A acts as a lactyltransferase to lactylate histone H3, leading to expression of Wnt/β-catenin, NFκB, and PD-L1, and brain tumor growth and immune evasion.

2024-10-01 | GSE278139 | GEO

Sequencing of proximal tubular carnitine-acetyl transferase knockout kidney cortex from mouse

Project description:Sequencing of proximal tubular carnitine-acetyl transferase knockout kidney cortex from mouse

| PRJNA874699 | ENA

Kat2a regulates hippocampal memory formation [RNA-seq]

Project description:We sequenced mRNA from 24 samples extracted from mouse CA1 tissue to generate the first CA1-specific murine transcriptome and the first CA1-transcriptome in response to environmental novelty under normal and Kat2a-loss-of-function conditions. Samples were divded in 4 groups: A: Control naM-CM-/ve (n=6), B: control novelty-exposed (n=5), C: Kat2a cKO naM-CM-/ve (n=6), D: Kat2a cKO novelty-exposed (n=7). Pairwise comparisons for AvsB, AvsC, BvsD and CvsD were performed using DESeq2.

2014-07-16 | E-GEOD-53380 | biostudies-arrayexpress

Histone acetyltransferase Kat2a stabilises pluripotency with control of transcriptional heterogeneity

Project description:Cell fate transitions in mammalian stem cell systems have often been associated with transcriptional heterogeneity, however existing data have failed to establish a functional or mechanistic link between the two phenomena. Experiments in unicellular organisms support the notion that transcriptional heterogeneity can be used to facilitate adaptability to environmental changes and have identified conserved chromatin-associated factors that modulate levels of transcriptional noise. By inhibiting the paradigmatic histone acetyl-transferase, and candidate noise modulator, Kat2a (yeast orthologue Gcn5) in mouse embryonic stem cells, we show destabilisation of pluripotency-associated gene regulatory networks through increased global and locus-specific transcriptional heterogeneity. Functionally, network destabilisation associates with reduced pluripotency and accelerated mesendodermal differentiation, with increased probability of transitions into lineage commitment. Thus, we functionally link transcriptional heterogeneity to cell fate transitions through manipulation of the histone acetylation landscape of mouse embryonic stem cells and establish a general paradigm that could be exploited in other normal and malignant stem cell fate transitions.

2019-01-20 | GSE114797 | GEO

Sequencing of proximal tubular carnitine-acetyl transferase Heterozygous knockout kidney cortex from mouse

Project description:Sequencing of proximal tubular carnitine-acetyl transferase Heterozygous knockout kidney cortex from mouse

| PRJNA718876 | ENA