Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan]

ABSTRACT: Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan]

PROVIDER: PRJNA528213 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan]

Project description:Breast cancer in Spain remains the first leading cause of cancer-related death in women from all age, and in younger women breast tumors often exhibit more aggressive phenotypes, worse prognosis and more frequently germline mutation in BRCA1/2 genes. Chromothripsis, a massive genome rearrangement, has been recently described but its etiology and effect on cancer cells remain unknown. Chromothripsis in breast cancer has been poorly studied and prevalence rates vary between 11-61%. We have studied chromothripsis-like patterns (CTLPs) in 58 DNA extracted from formalin-fixed paraffin-embedded (FFPE) breast cancer tissues from patients below 40 years old. Chromothripsis was confirmed with website tool CTLPScanner in 10/58 (17%) and most frequently involved chromosomal segment was 17q12-q21 (5/10 cases, 50%). We have also find that chromothripsis was related to low recurrence rates and familial history of breast cancer. In summary, we have analyzed chromothripsis in early-onset breast cancer for the first time and could have a prognostic value for this patients

2021-03-31 | GSE128584 | GEO

Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan_CNV]

2021-03-31 | GSE128586 | GEO

Chromothripsis is a prognostic factor in early-onset breast cancer [CytoScan750K_Array]

2021-03-31 | GSE128583 | GEO

Chromothripsis is a prognostic factor in early-onset breast cancer

Project description:Chromothripsis is a prognostic factor in early-onset breast cancer

| PRJNA528208 | ENA

Chromothripsis is a prognostic factor in early-onset breast cancer [CytoScan750K_Array]

Project description:Chromothripsis is a prognostic factor in early-onset breast cancer [CytoScan750K_Array]

| PRJNA528200 | ENA

Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan_CNV]

Project description:Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan_CNV]

| PRJNA528214 | ENA

Chromothripsis is a prognostic factor in early-onset breast cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-31 | GSE128587 | GEO

Oncoscan for HER2 copy number assessment

Project description:Affymetrix Oncoscan arrays were performed according to the manufacturer's directions on DNA extracted from FFPE-breast cancer tissues. Copy number analysis using Affymetrix Oncoscan arrays was performed for 29 primary breast cancers

2016-07-01 | E-GEOD-83916 | biostudies-arrayexpress

chromothripsis in neuroblastoma

Project description:chromothripsis in neuroblastoma

| PRJEB671 | ENA

Genome sequencing of childhood medulloblastoma brain tumors links chromothripsis with TP53 mutations

Project description:Genomic rearrangements typically occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving chromosome shattering and reshuffling ('chromothripsis'), for which no genetic basis has yet been described. Whole-genome sequencing of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation (Li-Fraumeni syndrome) revealed massive, complex rearrangements resulting from chromothripsis. Integrating TP53 status with genomic rearrangement data in additional medulloblastomas revealed a striking association between TP53 mutation and chromothripsis in SHH-MBs. Unexpectedly, five seemingly sporadic SHH-MB patients with chromothripsis harbored TP53 germline mutations – findings relevant for clinical management. Analysis of additional tumor entities substantiated a link between TP53 mutation and chromothripsis, beyond general genomic instability. Among these, we observed a strong association between somatic TP53 mutations and chromothripsis in acute myeloid leukemia. These findings implicate p53 in the initiation of, or cellular reaction to, chromothripsis – a novel role for the 'guardian of the genome'.

2012-01-20 | GSE34258 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data