Project description:Free fatty acid beta oxidation and Akt signal pathway process were up-regulated in liver of Balb/cBy mice after 12 week HFD-fed, which can conrtibute to up-regulate free fatty acid beta oxidation and improve insulin signal transduction We used microarrays to detail the global gene expression underlying free fatty acid beta oxidation, unfolded protein response and Akt signal pathway, and then identified up-regulated and down-regulated genes during there process.
Project description:Free fatty acid β oxidation and akt signal pathway processes were up-regulated in liver of Balb/cBy mice after 12 week HFD-fed, which can conrtibute to up-regulate free fatty acid β oxidation and improved insulin signal transduction We used microarrays to detail the global genes expression underlying free fatty acid β oxidation, unfolded protein response and akt signal pathway, and then identified up-regulated and down-regulated genes during there processes.
Project description:Lck-MyrAkt2 mice develop spontaneous thymic lymphomas at approximately 100-200 days of age, driven in part by a consitutatively-active AKT (due to myristoylation). mTOR Knock Down mice were crossed with Lck-MyrAkt postive mice to model the affects of decreasing mTOR activity on tumors with an activated PI3K/AKT/MTOR pathway. Lck-Akt/mTOR KD mice had prolonged survival compared to the Lck-Akt/mTOR WT mice. We used microarrays to compare the transcriptome in thymic lymphomas between Lck-Akt positive, mTOR WT and Lck-Akt positive, mTOR KD mice. Four thymic lymphomas from Lck-Akt/mTOR WT mice were compared to three thymic lymphomas from Lck-Akt/mTOR KD mice.
Project description:In this study, we compare the transcriptomic difference between WT and Chd8 depleted ES aand differentiating ES cells. We report significant differences between Chd8 WT and KD/KO cell lines.
Project description:Lysosome-enriched fractions from the liver of Cln8 KO mice and WT mice. Included are four datasets: 1. Lysosome-enriched fraction from the liver of Cln8 KO mice, replicate 1 (CLN8_KO_1). 2. Lysosome-enriched fraction from the liver of Cln8 KO mice, replicate 2 (CLN8_KO_2). 3. Lysosome-enriched fraction from the liver of WT mice, replicate 1 (WT_1). 4. Lysosome-enriched fraction from the liver of WT mice, replicate 2 (WT_2).
Project description:Expression profiling by microarray was used with a murine listeriosis model to better understand increased susceptibility of preterm neonates to infection. We used DNA microarray to identify genes that were differentially expressed in liver of adult and neonatal Balb/c mice after listeriosis infection.