Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome of human endothelial cells treated with R-2HG or S-2HG

ABSTRACT: Transcriptome of human endothelial cells treated with R-2HG or S-2HG

PROVIDER: PRJNA528313 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8758290.fastq.gz	Fastqsanger.gz
	SRR8758291.fastq.gz	Fastqsanger.gz
	SRR8758283.fastq.gz	Fastqsanger.gz
	SRR8758284.fastq.gz	Fastqsanger.gz
	SRR8758285.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Transcriptome of human endothelial cells treated with R-2HG or S-2HG

Project description:Transcriptome profiling of human umbilical vein endothelial cells (HUVECs) treated with R-2HG or S-2HG to identify isomer-specific gene regulation.

2021-01-05 | GSE128633 | GEO

Transcriptional regulation by FOXO1 and 2HG in human endothelial cells

Project description:Transcriptional regulation by FOXO1 and 2HG in human endothelial cells

| PRJNA528311 | ENA

Transcriptome analysis of TWIST1 sgRNA-treated human tumor endothelial cells

Project description:Transcriptome analysis of TWIST1 sgRNA-treated human tumor endothelial cells

| PRJNA916898 | ENA

The anti-leukemic effect of R-2HG depends on its acting as an m6A mRNA modifier-RNA Seq-PBS / R-2HG treatment

Project description:RNA-seq from R-2HG sensitive leukemia cells treated with R-2HG or PBS.

2017-12-14 | GSE87189 | GEO

Transcriptome analysis of TWIST1 sgRNA-treated human tumor endothelial cells

Project description:The global RNA expression was assayed on human glioblastoma-derived tumor endothelial cells (ECs) treated with CRISPR/sgRNA targeting Twist1 or control sequence.

2023-02-15 | GSE221950 | GEO

Comparison of STEEL siRNA-treated and control siRNA-treated human endothelial cells

Project description:Comparison of STEEL siRNA-treated and control siRNA-treated human endothelial cells

| PRJNA423090 | ENA

RNA-seq analysis after MIR4435-2HG knockdown in HemECs

Project description:Infantile hemangiomas (IHs) are commonly observed benign tumors that can cause serious complications.In this study, we investigated the role of M2 macrophage-derived exosomal lncRNA MIR4435-2HG in IHs. Exosomes derived from M2 polarized macrophages were extracted. Next, using cell co-culture or transfection, we investigated whether M2 polarized macrophage-derived exosomes (M2-exos) can transport MIR4435-2HG to regulate the proliferation, migration, invasion, and angiogenesis of hemangioma-derived endothelial cells (HemECs). RNA-seq and RNA pull-down assays were performed to identify targets and regulatory pathways of MIR4435-2HG. We explored the possible mechanisms through which MIR4435-2HG regulates the biological function of HemECs.We found that M2-exos significantly enhanced the proliferation, migration, invasion, and angiogenesis of HemECs. Thus, HemECs uptake M2-exos and promote biological functions through the inclusion of MIR4435-2HG. RNA-seq and RNA pull-down experiments confirmed that MIR4435-2HG regulates of HNRNPA1 expression and directly binds to HNRNPA1, consequently affecting the NF-κB signal pathway.In conclusion, MIR4435-2HG of M2-exos promotes the progression of IHs and enhances the proliferation, migration, invasion, and angiogenesis of HemECs by directly binding to HNRNPA1. This study not only reveals the mechanism of interaction between M2 macrophages and HemECs, but also provides a promising therapeutic target for IHs.

2023-10-29 | GSE236203 | GEO

The effect of 2HG level on transcriptome at different stages of male mouse meiosis

Project description:We found that L2-hydroxyglutarate (2HG) level is 15 times higher in pachytene-diplotene (PD) stage as compared to leptotene-zygotene (LZ) stage. Since 2HG shows epigenetic effects we asked if the addition of 2HG to LZ cells or the decrease of 2HG level in PD cells will cause changes in gene expression.

2022-05-31 | GSE169014 | GEO

RNA-seq of CYR61-treated human umbilical vein endothelial cells

Project description:RNA-seq of CYR61-treated human umbilical vein endothelial cells

| PRJNA917719 | ENA

Transcriptomic profiling of simvastatin-treated human umbilical vein endothelial cells

Project description:Transcriptomic profiling of simvastatin-treated human umbilical vein endothelial cells

| PRJNA718475 | ENA