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TWIST1 regulated human melanoma transcriptome

ABSTRACT: TWIST1 regulated human melanoma transcriptome

PROVIDER: PRJNA529486 | ENA |

REPOSITORIES: ENA

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TWIST1 regulated human melanoma transcriptome

Project description:TWIST1 is known to play a role in the metastatic progression of melanoma. However, the range of TWIST1 targets is poorly charachterized. Here microarray analysis was used to define the TWIST1 regulated transcriptome in the human melanoma cell line WM793.

2019-04-03 | GSE128955 | GEO

TWIST1

Project description:TWIST1

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Transcriptome drift of FADU after expression of HIF-1a, Twist1 or Bmi1

Project description:Expression of HIF-1a or Twist1 or Bmi1 in human hypopharyngeal cancer cell line FADU results in the drift of transcriptome profile from an epithelial cell-like signature to a mesenchymal stem cell-like signature. Stable transfection of pHA-HIF1a(dODD), pFLAG-Twist1 or pcDNA3-Bmi1 in FADU cell and analyzed the transcriptome by cDNA microarray. FADU transfected with pcDNA3.1 empty vector was used as a control of experiment.

2010-12-10 | E-GEOD-19406 | biostudies-arrayexpress

Genes regulated by DNMT1 in WM266.4 human melanoma cells

Project description:Genes regulated by DNMT1 in WM266.4 human melanoma cells

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Transcriptome analysis of TWIST1 sgRNA-treated human tumor endothelial cells

Project description:Transcriptome analysis of TWIST1 sgRNA-treated human tumor endothelial cells

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Transcriptome analysis of TWIST1 sgRNA-treated human tumor endothelial cells

Project description:The global RNA expression was assayed on human glioblastoma-derived tumor endothelial cells (ECs) treated with CRISPR/sgRNA targeting Twist1 or control sequence.

2023-02-15 | GSE221950 | GEO

Transcriptome drift of FADU after expression of HIF-1a, Twist1 or Bmi1

2010-12-10 | GSE19406 | GEO

Twist1 knockdown in two gastric cancer-associated fibroblast lines

Project description:Primary human gastric cancer-associated fibroblast (CAF) cultures (CAF14 and CAF32) were establised from 2 gastrectomy specimens. Silencing the expression (loss-of-function effect) of Twist1 in CAFs showed candidate target genes regulated by Twist1 and abrogated their tumor-promoting properties.

2014-10-28 | GSE62738 | GEO

Differential regulation of Twist1-responsive genes in 4T1 cells

Project description:Twist1 variants including wildtype Twist1, a non-phosphorylatable mutant Twist1/S42A and a phospho-mimicking mutant Twist1/S42D were expressed in 4T1 cells in which the endogenous Twist1 was depleted. We wanted to use microarray analysis to evaluate those genes that are differentially regulated by Twist1 variants.

2012-05-01 | GSE29754 | GEO

Identification of TWIST1-associated genomic regions in human breast cancer cell MCF7

Project description:In this study, we aimed to characterize the stimulatory role of TWIST1 in breast cancer cell proliferation, EMT and metastasis, uncover the underlying molecular mechanism, and identify potential therapeutic targets for treating BLBC. RNA-Seq analysis were performed to identify differentially expressed genes influenced by TWIST1 overexpression in breast cancer cell MCF7. Pathway enrichment analysis and gene set enrichment analysis were performed to identify TWIST1-regulated signaling pathways, particually the cancer-associated pathways. ChIP-Seq analysis was further performed to identify TWIST1-associated genomic regions in MCF7-TWIST1 cells. The potential direct target genes of TWIST1 were identified by combined analysis of the gene expression profiling data and ChIP-Seq data.

2022-06-28 | GSE189826 | GEO

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