Project description:Analysis of SCC-15 tongue cancer cells overexpressing miR-611. miR-611 is frequently upregulated in primary tongue cancer. Results provide insight into the role of miR-611 in the pathogenesis of tongue cancer. We used micorarrays to detailed the genes regulated by miR-611 in SCC-15 cells.
Project description:Analysis of SCC-15 tongue cancer cells overexpressing miR-762. miR-762 is frequently upregulated in primary tongue cancer. Results provide insight into the role of miR-762 in the pathogenesis of tongue cancer. We used micorarrays to detailed the genes regulated by miR-762 in SCC-15 cells.
Project description:Analysis of SCC-9 tongue cancer cells overexpressing miR-585-5p. miR-585-5p is frequently downregulated in primary tongue cancer. Results provide insight into the role of miR-585-5p in the pathogenesis of tongue cancer. We used micorarrays to detailed the genes regulated by miR-585-5p in SCC-9 cells.
Project description:We aimed to determine whether overexpression of endoderm-specific miRNA may affect hESC differentiation. To this end, we analyzed the effect of lentiviral-based overexpression of liver-specific miR-122 on hESC differentiation, using genomewide gene microarrays. Stable overexpression of endoderm-specific miR-122 in hESC resulted in increased expression of a few endodermal markers in spontaneously-differentiating hESC, but had no clear effect on directing differentiation towards an endodermal fate; rather, it delayed the general differentiation of hESC.