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Lymphatic endothelial cell identity is controlled by a GATA2 bound enhancer [RNA-seq]

ABSTRACT: Lymphatic endothelial cell identity is controlled by a GATA2 bound enhancer [RNA-seq]

PROVIDER: PRJNA532346 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8882027_1.fastq.gz	Fastqsanger.gz
	SRR8882027_2.fastq.gz	Fastqsanger.gz
	SRR8882028_1.fastq.gz	Fastqsanger.gz
	SRR8882028_2.fastq.gz	Fastqsanger.gz

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Lymphatic endothelial cell identity is controlled by a GATA2 bound enhancer

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Lymphatic endothelial cell identity is controlled by a GATA2 bound enhancer [RNA-seq]

Project description:Transcriptional enhancer elements are responsible for orchestrating the temporal and spatial control over gene expression that is crucial for programming cell identity during development. Here, we describe a novel enhancer element important for regulating Prox1 expression in lymphatic endothelial cells. This evolutionarily conserved enhancer is bound by key lymphatic transcriptional regulators including GATA2, FOXC2, NFATC1 and PROX1. CRISPR-Cas9 genome editing of this enhancer element revealed that deletion of only 5 nucleotides encompassing the GATA2 binding site has a dramatic impact on lymphatic vascular development; mice homozygous for this deletion die soon after birth exhibiting profound lymphatic vascular defects. Lymphatic endothelial cells in enhancer mutant mice exhibit reduced levels of genes characteristic of lymphatic endothelial cell identity and acquire characteristics of hemogenic endothelium, including the capacity to generate hematopoietic cells. These data reveal the first transcriptional enhancer element important for regulating Prox1 expression and lymphatic endothelial cell identity and suggest that Prox1 is important for repressing hemogenic cell identity in the lymphatic endothelium.

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Lymphatic endothelial cell identity is controlled by a GATA2 bound enhancer (RNA-Seq)

Project description:This study investigates the impact on the transcriptome of lymphatic endotheial cells of a 5bp deletion (GATA2 binding site) in an enhancer element 11kb upstream of the Prox1 gene.

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Lymphatic endothelial cell identity is controlled by a GATA2 bound enhancer (Microarray)

Project description:This study investigates the transcriptome of primary dermal lymphatic endothelial cells compared with blood vascular endothelial cells using samples isolated from wildtype embryos at defined points (E14.5, E16.5 and E18.5) during mouse embryonic development.

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Lymphatic endothelial cell identity is controlled by a GATA2 bound enhancer

Project description:This SuperSeries is composed of the SubSeries listed below.

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