Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-sequencing of cultured young (2-3mos) and aged (20-22mos) mouse brain ILC2

ABSTRACT: RNA-sequencing of cultured young (2-3mos) and aged (20-22mos) mouse brain ILC2

PROVIDER: PRJNA533456 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8925310.fastq.gz	Fastqsanger.gz
	SRR8925320.fastq.gz	Fastqsanger.gz
	SRR8925330.fastq.gz	Fastqsanger.gz
	SRR8925311.fastq.gz	Fastqsanger.gz
	SRR8925321.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

RNA-sequencing of cultured young (2-3mos) and aged (20-22mos) mouse brain ILC2

Project description:We investigated how aging impacts the ILC2 population in the brain. Through RNA-sequencing of 2-week culture of sorted brain ILC2 from young and aged mice,we identified differential gene expressions regarding cellular exhaustion and self-renewal between young and aged brain ILC2.

2020-01-21 | GSE129992 | GEO

RNA-sequencing of microglia, T cells and ILC2 from the brains of IL-33 treated aged (20-22mos) mice

Project description:ILC2 are potent producers of IL-5 and IL-13 and Th2 cytokines have been found to promote neurogenesis and cognitive functions. We report microglia, brain T cells and ILC2 have a range of differentially expressed genes in IL-33 treated aged mice. Brain ILC2 upregulated a range of neuroprotective genes.

2020-01-21 | GSE129996 | GEO

scRNA-sequencing of ILC2 sorted from the choroid plexus and meninges of IL-33 treated aged (20-22 mos) mice

Project description:ILC2 are potent producers of IL-5 and IL-13 and Th2 cytokines. We have found that they promote neurogenesis and cognitive functions in aged mice . We report that CP and meningeal ILC2 from IL-33 treated aged mice have differential expression of Th2 cytokines as well as genes involved in metabolism through scRNA-sequencing.

2020-01-21 | GSE139328 | GEO

Aged, Young and Restored Samples from Mobilized Peripheral Blood [mRNA]

Project description:We report the gene expression changes in mobilized peripheral blood in aged, young, and aged/young samples cocultured in transwell. Restored samples refer to aged MPB co-cultured with young MPB in the transwell culture

2021-12-01 | GSE138563 | GEO

RNA sequencing of young and old lung ILC2 cells

Project description:ILC2 cells from young and old mouse lungs were analysed and revealed altered transcriptome of old ILC2 compared to the young.

2022-01-23 | GSE125584 | GEO

Aged, Young and Restored Samples from Mobilized Peripheral Blood [miRNA]

Project description:We report the miRNA expression in each CD34+ cells and their exosomes in mobilized peripheral blood in aged, young, and aged/young samples cocultured in transwell. Restored samples refer to aged MPB co-cultured with young MPB in the transwell culture.

2021-12-01 | GSE138564 | GEO

Young and aged Myeloid cell treatment with EP2 antagonist PF044

Project description:Peritoneal macrophages from young (3-4mo.) and aged (20-22mo.) mice were isolated from mice treated with EP2 antagonist PF044 (2.5mg/kg/d) for 6 weeks.

2020-11-24 | GSE155992 | GEO

Young and aged mouse bladders

Project description:Young and aged mouse bladders

| PRJNA629290 | ENA

Genome-wide microarray analysis on choroid plexus of young and aged mice

Project description:Aging induces cognitive decline and Th2 cytokines have been found to promote neurogenesis and cognitive functions. ILC2 are potent producers of IL-5 and IL-13. The role of ILC2 in cognitive function in the context of aging has not been investigated. We report tissue resident ILC2 accumulate in the choroid plexus of the brain in aged mice. They are long-lived and can switch between cellular dormancy and proliferation in response to replication stress. ILC2 play a direct role in promoting the cognitive functions in aged mice, through producing IL-5. IL-5 has neuroprotective functions including neurogenesis and reducing pro-inflammatory functions of microglia in aged mice.

2020-01-21 | GSE129923 | GEO

Single cell RNA sequencing of myeloid cells from lungs of young and aged mice

Project description:Single cell RNA sequencing from lungs of young (2-3 month old) and aged (20-22 month old) mice.

2021-10-20 | GSE167236 | GEO