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Effect of miRNA-30e-5p on innate immunity during viral infection.

ABSTRACT: Effect of miRNA-30e-5p on innate immunity during viral infection.

PROVIDER: PRJNA533544 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8926580_1.fastq.gz	Fastqsanger.gz
	SRR8926580_2.fastq.gz	Fastqsanger.gz
	SRR8926575_1.fastq.gz	Fastqsanger.gz
	SRR8926575_2.fastq.gz	Fastqsanger.gz
	SRR8926576_1.fastq.gz	Fastqsanger.gz

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Effect of miRNA-30e-5p on innate immunity during viral infection.

Project description:Comparative transcriptomic analysis of A549 cell after overexpression of miRNA-30e-5p revealed that miRNA-30e-5p elevate innate immune responses by targeting the negative regulators of innate immune signalling.

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Synthetic double stranded RNA reliably induces innate immunity similar to a live viral vaccine in humans

Project description:Adjuvants are critical for the success of vaccines, and agonists for microbial pattern recognition receptors are promising new candidates. A mechanism for the immune enhancing role of adjuvants is to stimulate innate immunity. We studied the innate immune response in humans to synthetic double stranded RNA (poly ICLC), a ligand for TLR3 and MDA-5 cytosolic RNA helicase. Transcriptional analysis of blood samples from eight volunteers, after subcutaneous administration of poly ICLC showed upregulation of genes involved in multiple innate immune pathways in all subjects, including interferon and inflammasome signaling. Blocking of type I interferon receptor ex vivo significantly dampened the response to poly IC. Comparative transcriptional analysis showed that several innate pathways were similarly induced in volunteers immunized with the highly efficacious Yellow Fever Vaccine. Therefore a chemically defined microbial agonist like poly ICLC can be a reliable and authentic microbial mimic for inducing innate immunity, here for a live attenuated viral vaccine in humans. GSM813292-GSM813386: RNA expression obtained at different time points from Human blood after poly ICLC administration compared to RNA expression obtained from Human blood after placebo administration GSM813387-GSM813410: Blocking of type I interferon receptor ex vivo followed by poly IC stimulation

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Combating viral contaminants in CHO cells by engineering innate immunity

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Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity

Project description:Innate immunity serves as the primary defense against viral and microbial infections in humans. Among its components, retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are well-characterized intracellular pattern-recognition proteins that trigger innate immune responses upon viral infection. However, the precise influence of cellular metabolites, especially fatty acids, on the regulation of RLR-mediated antiviral innate immunity remains largely elusive. Here, through screening a metabolite library, palmitic acid (PA) has been identified as a crucial metabolite responsible for modulating antiviral infections. Mechanistically, PA induces the palmitoylation of MAVS, leading to MAVS aggregation and subsequent activation, thereby enhancing the innate immune response against viral infections. Functionally, the enzyme palmitoyl-transferase ZDHHC24 plays a key role in catalyzing the palmitoylation of MAVS at both C46 and C79 residues, thereby facilitating the transduction of RLR-mediated TBK1-IRF3-IFN signaling pathway, particularly under conditions of PA stimulation or high-fat diet feeding. Conversely, the absence of ZDHHC24 significantly attenuates virus-induced innate immune responses in both cells and mice. Moreover, APT2 counteracts with ZDHHC24 to de-palmitoylate MAVS, thus inhibiting the antiviral response. Consequently, inhibition of APT2 using compounds like ML349 effectively reverses MAVS palmitoylation and activation in response to antiviral infections. These findings underscore the critical role of PA and ZDHHC24 in regulating antiviral innate immunity through MAVS palmitoylation, and suggest potential therapeutic strategies for combating viral infections, such as enhancing PA intake or specifically targeting APT2.

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Transcription profiling of Drosophila infected with Drosophila C virus reveals a third evolutionary conserved innate immunity pathway operates in drosophila and counters viral infection

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The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity [RNA-seq]

Project description:The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity [RNA-seq]

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The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity [ChIP-seq]

Project description:The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity [ChIP-seq]

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