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Hippo signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions [MoGene-2_0]

ABSTRACT: Hippo signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions [MoGene-2_0]

PROVIDER: PRJNA533632 | ENA |

REPOSITORIES: ENA

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Hippo signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions [MoGene-2_0]

Project description:Hippo kinases Mst1 and Mst2 act as molecular rheostats for the terminal maturation and effector differentiation programs of iNKT cells. iNKT developmental stages 1, 2, and 3 (S1, S2, S3) were sorted from the thymus of WT (n = 3) and Cd4CreMst1fl/fl (n = 3) mice

2020-04-07 | GSE130043 | GEO

Hippo signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions [ClariomS]

Project description:Hippo kinases Mst1 and Mst2 act as molecular rheostats for the terminal maturation and effector differentiation programs of iNKT cells. Loss of Mst1 alone or with Mst2 impedes iNKT cell development, associated with defective IL-15-dependent cell survival

2020-04-18 | GSE144776 | GEO

Hippo signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions

Project description:Hippo signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions

| PRJNA604829 | ENA

Hippo signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions [ClariomS]

Project description:Hippo signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions [ClariomS]

| PRJNA604837 | ENA

Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.

Project description:Invariant natural killer T (iNKT) cells acquire effector functions during development by mechanisms that remain poorly understood. Here, we show that the Hippo kinases Mst1 and Mst2 act as molecular rheostats for the terminal maturation and effector differentiation programs of iNKT cells. Loss of Mst1 alone or together with Mst2 impedes iNKT cell development, associated with defective IL-15-dependent cell survival. Mechanistically, Mst1 enforces iNKT cellular and transcriptional quiescence associated with maturation and commitment to iNKT1 cells by suppressing proliferation and Opa1-related mitochondrial metabolism that are dynamically regulated during iNKT cell development. Furthermore, Mst1 shapes the reciprocal fate decisions between iNKT1 and iNKT17 effector cells, which respectively depend upon mitochondrial dynamics and ICOS-mTORC2 signaling. Collectively, these findings establish Mst1 as a crucial regulator of mitochondrial homeostasis and quiescence in iNKT cell development and effector lineage differentiation and highlight that establishment of quiescence programs underlies iNKT cell development and effector maturation.

| S-EPMC7971129 | biostudies-literature

Role of BAP1 in pancreatic cancer (MoGene-2_0)

Project description:Role of BAP1 in pancreatic cancer (MoGene-2_0)

| PRJNA491696 | ENA

LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity [MoGene-2_0-st]

Project description:LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity [MoGene-2_0-st]

| PRJNA527817 | ENA

Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye

Project description:The canonical function of the Hippo signaling pathway is the regulation of organ growth. How this pathway controls cell fate determination is less well understood. Here, we identify a function of the Hippo pathway in cell fate decisions in the developing Drosophila eye, exerted through the interaction of Yorkie (Yki) with the transcriptional regulator Bonus (Bon), an ortholog of mammalian Transcriptional Intermediary Factor 1/tripartite motif (TIF1/TRIM) family proteins. Instead of controlling tissue growth, Yki and Bon promote epidermal and antennal fates at the expense of the eye fate. Proteomic, transcriptomic, and genetic analyses reveal that Yki and Bon control these cell fate decisions by recruiting transcriptional and post-transcriptional co-regulators, and by repressing Notch target genes and activating epidermal differentiation genes. Our work expands the range of functions and regulatory mechanisms under Hippo pathway control.

2023-01-17 | GSE181299 | GEO

Hippo signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-04-07 | GSE144778 | GEO

Gene expression from ErbB2-driven mamamry tumors (MMTV-NIC model) with beta 1 integrin KO, beta 3 integrin KO or beta 1/beta 3 double KO

Project description:In this study, we used conditional knockout and gene expression approaches to understand global molecular and transciptional changes due to ablation of each integrin subunit. Affymetrix MoGene-2_0-st-v1 gene chip

2019-08-23 | GSE136214 | GEO

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