Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profile in Caco-2 cells upon co-treatment with lovastatin and selective AHR ligands

ABSTRACT: Gene expression profile in Caco-2 cells upon co-treatment with lovastatin and selective AHR ligands

PROVIDER: PRJNA534335 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8947480.fastq.gz	Fastqsanger.gz
	SRR8947481.fastq.gz	Fastqsanger.gz
	SRR8947482.fastq.gz	Fastqsanger.gz
	SRR8947483.fastq.gz	Fastqsanger.gz
	SRR8947484.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Gene expression profile in Caco-2 cells upon co-treatment with lovastatin and selective AHR ligands

Project description:We report high-throughput profiling of gene expression from human colon adenocarcinoma Caco-2 line. We profile mRNA in lovastatin-treated cells, and examine the effect of AHR ligands, SGA360 or SGA315. This study provides a framework for understanding transcriptional changes caused by SGA360 or SGA315 during upon lovastatin use.

2020-04-23 | GSE130234 | GEO

Endothelial sensing of AHR ligands regulates intestinal barrier immunity [AHR KO RNA-seq]

Project description:Endothelial sensing of AHR ligands regulates intestinal barrier immunity [AHR KO RNA-seq]

| PRJNA932742 | ENA

Endothelial sensing of AHR ligands regulates intestinal barrier immunity

Project description:Endothelial sensing of AHR ligands regulates intestinal barrier immunity

| PRJNA833035 | ENA

Endothelial sensing of AHR ligands regulates intestinal barrier immunity [LEC_SI]

Project description:Endothelial sensing of AHR ligands regulates intestinal barrier immunity [LEC_SI]

| PRJNA833040 | ENA

Endothelial sensing of AHR ligands regulates intestinal barrier immunity [BEC_SI]

Project description:Endothelial sensing of AHR ligands regulates intestinal barrier immunity [BEC_SI]

| PRJNA833041 | ENA

Endothelial sensing of AHR ligands regulates intestinal barrier immunity [scRNAseq]

Project description:Endothelial sensing of AHR ligands regulates intestinal barrier immunity [scRNAseq]

| PRJNA833044 | ENA

Endothelial sensing of AHR ligands regulates intestinal barrier immunity [Hg bulkRNAseq]

Project description:Endothelial sensing of AHR ligands regulates intestinal barrier immunity [Hg bulkRNAseq]

| PRJNA833030 | ENA

Endothelial sensing of AHR ligands regulates intestinal barrier immunity [AHR KO RNA-seq]

Project description:The blood and lymphatic vasculature is lined by functionally specialised endothelial cells (ECs). In the intestine, ECs act as an essential physical barrier, controlling nutrient transport, facilitating tissue immunosurveillance, and coordinating angiogenesis and lymphangiogenesis to ensure appropriate tissue perfusion and drainage. Conversely, endothelial maladaptation can lead to pathological angiogenesis and the perpetuation of inflammation in chronic inflammatory diseases. However, whether enteric ECs actively engage in the regulation of intestinal homeostasis and pathology through integration of environmental cues is currently unknown. Here, we show that the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, acts as critical node for EC-sensing of dietary and microbial metabolites. We first established a comprehensive single-cell endothelial atlas of the mouse small intestine uncovering the cellular complexity and functional heterogeneity of blood and lymphatic ECs, identifying transcriptional networks and putative biological roles across endothelial subtypes. Analyses of AHR mediated responses at single-cell resolution identified tissue-protective transcriptional signatures and regulatory networks promoting quiescence and vasculoprotection. Endothelial AHR-deficiency in mice resulted in cellular activation, proliferation, and initiation of angiogenic pathways disrupting tissue homeostasis. In human ECs, AHR signalling promoted quiescence through cell cycle arrest and tempered endothelial inflammatory responses. Together, our data provide a comprehensive dissection of the impact of environmental sensing across the spectrum of enteric endothelia, demonstrating that endothelial AHR signalling serves to promote homeostasis and prevent aberrant inflammatory responses at the intestinal barrier.

2023-07-12 | GSE224806 | GEO

Endothelial sensing of AHR ligands regulates intestinal barrier immunity [LEC_SI]

2023-07-12 | GSE201788 | GEO

Endothelial sensing of AHR ligands regulates intestinal barrier immunity [BEC_SI]

2023-07-12 | GSE201785 | GEO