Project description:1. Fermentative activities of colon microbiota pre-exposed to celecoxib oscillate and endure irreversible modifications following continuous NSAID supplementation in a simulated model of the gut microbial ecosystem
Project description:Celecoxib builds up and cues metabolically active bacteria inhabiting the mucosal environment of a simulated human intestinal ecosystem, modulating inflammatory response
Project description:Decreased diversity of butyrate-producing bacteria followed by functional adjustment occurs in the microbiome of the simulated proximal colon upon long-term treatment with aspirin
Project description:Understanding the biogeographical patterns and underlying drivers of microbial functional diversity is essential for anticipating climate change impacts on ecosystem functioning worldwide. However, this matter remains scarcely addressed in freshwater ecosystems. Using the high-throughput gene array GeoChip 4.0, we show that functional gene alpha diversity and compositon differ across mountains, alpha diversity declines towards high elevations and compositional turnover increases with larger elevational distances. Both continental- and mountain-scale patterns were primarily driven by climatic variables.
Project description:We used microarrays to unveil the gene expression alterations upon short-term HFD administration We found that short-term HFD administration impacts hepatic lipid biosynthesis and redox status
Project description:Essential oil supplementation in milk replacers: short- and long-term impacts on feed efficiency, the faecal microbiota and the plasma metabolome in dairy calves
