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Transcriptomic alterations of erythroid progenitors during ageing

ABSTRACT: Transcriptomic alterations of erythroid progenitors during ageing

PROVIDER: PRJNA541133 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9015610.fastq.gz	Fastqsanger.gz
	SRR9015611.fastq.gz	Fastqsanger.gz
	SRR9015606.fastq.gz	Fastqsanger.gz
	SRR9015607.fastq.gz	Fastqsanger.gz
	SRR9015608.fastq.gz	Fastqsanger.gz

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Transcriptomic alterations of erythroid progenitors during ageing

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Project description:CD34-positive cells from peripheral blood were culture for 5 days in erythroid differentiating medium. Four progenitor stages were sorted by FACS using the established cell surface markers CD34 and CD36 with CD117, CD71, and CD105 (Yan H, Am J Hematol, 2021). A comprehensive analysis of the proteome of these four erythroid progenitor stages was done in quadruplicate using a label free proteomic approach.

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Erythroid progenitors stimulated with EPO

Project description:CD34+ progenitors were isolated from the bone marrow of three healthy volunteers. CD34+CD71+CD45RA- were FACS sorted to enrich for erythroid progenitors. The cells were cultured for four hours with or without EPO in combination with LY294002, and harvested for RNA extraction, amplification and expression analysis. A compound treatment design type is where the response to administration of a compound or chemical (including biological compounds such as hormones) is assayed. Compound Based Treatment: EPO Keywords: compound_treatment_design

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2023-12-31 | GSE190030 | GEO

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