Project description:Background: Gastrointestinal symptoms in COVID-19 patients suggests that the gut may present a viral target organ. Disease development and severity is dependent on viral interaction with two cell surface human proteins, ACE2 and TMPRSS2, and on antiviral response which may lead to systemic hyperinflammatory syndrome and multiorgan dysfunction Understanding the host response to SARS-CoV-2 infection and the pathology of the disease will be greatly enhanced by the development of appropriate animal models. However, the virus does not grow in wild type mice and only induced mild disease in transgenic animals expressing human ACE2. Results: As there are known differences between immune response in laboratory mice and humans, the response of human gut developed as xenografts and host mouse gut following systemic LPS injections as a hyperinflammation model system was evaluated. Gene set enrichment analysis of significantly upregulated human and mouse genes revealed that a number of inflammatory and immune response pathways are commonly regulated in the two species. However, species differences were also observed. The analysis shows that the intestinal immune response to inflammation in humans and mice are generally very similar. However, certain human-specific diseases, such as COVID-19, can only be successfully studied in an experimental model of human tissue, such as the gut xenograft

2022-06-01 | GSE180795 | GEO

chicken gut metagenome Raw sequence reads-LIHUA0-57F

Project description:chicken Raw sequence reads--LIHUA0-57F

| PRJNA542013 | ENA

chicken Raw sequence reads--LIHUA57gut-environment

Project description:chicken Raw sequence reads--LIHUA57gut-environment

| PRJNA542023 | ENA

mouse gut metagenome Raw sequence reads

Project description:mouse gut metagenome Raw sequence reads Metagenome

| PRJNA476206 | ENA

chicken gut metagenome

Project description:Chicken gut metagenome