Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance

ABSTRACT: Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance

PROVIDER: PRJNA543289 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [humanRibominusRNAseq]

Project description:Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [humanRibominusRNAseq]

| PRJNA928733 | ENA

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [humanpolyARNAseq]

Project description:Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [humanpolyARNAseq]

| PRJNA928734 | ENA

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [zf3primeseq]

Project description:Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [zf3primeseq]

| PRJNA928736 | ENA

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [humanTTseq]

Project description:Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [humanTTseq]

| PRJNA928737 | ENA

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (mouseRNAseq)

Project description:Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (mouseRNAseq)

| PRJNA508379 | ENA

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (humanChIPseq)

Project description:Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (humanChIPseq)

| PRJNA543300 | ENA

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (zfChIPseq)

Project description:Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (zfChIPseq)

| PRJNA543302 | ENA

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (zfRNAseq)

Project description:Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance (zfRNAseq)

| PRJNA543299 | ENA

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [humanMut3primeseq]

Project description:Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [humanMut3primeseq]

| PRJNA928735 | ENA

Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance

Project description:RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We find disrupted nuclear RNA surveillance is oncogenic. Cyclin Dependent Kinase 13 (CDK13) is mutated in melanoma and patient-mutated CDK13 accelerates zebrafish melanoma. CDK13 mutation causes aberrant RNA stabilization. CDK13 is required for ZC3H14 phosphorylation, which is necessary and sufficient to promote nuclear RNA degradation. Mutant CDK13 fails to activate nuclear RNA surveillance, causing aberrant protein-coding transcripts to be stabilized and translated. Forced aberrant RNA expression accelerates melanoma in zebrafish. We find recurrent mutations in genes encoding nuclear RNA surveillance components in many malignancies, establishing nuclear RNA surveillance as a tumor-suppressive pathway. Activating nuclear RNA surveillance is crucial to avoid accumulation of aberrant RNAs and their ensuing consequences in development and disease.

2023-04-21 | GSE131334 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data