Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape

ABSTRACT: Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape

PROVIDER: PRJNA543574 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9057540.fastq.gz	Fastqsanger.gz
	SRR9057560.fastq.gz	Fastqsanger.gz
	SRR9057541.fastq.gz	Fastqsanger.gz
	SRR9057561.fastq.gz	Fastqsanger.gz
	SRR9057542.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 52

Similar Datasets

Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape [rna-seq]

Project description:Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape [rna-seq]

| PRJNA543041 | ENA

Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape [atac-seq]

Project description:Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape [atac-seq]

| PRJNA543575 | ENA

Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape [5hmc-seal-seq]

Project description:Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape [5hmc-seal-seq]

| PRJNA543043 | ENA

Integrative multi-omics analysis of intestinal organoid differentiation

Project description:Intestinal organoids accurately recapitulate epithelial homeostasis in vivo, thereby representing a powerful in vitro system to investigate lineage specification and cellular differentiation. Here, we applied a multi-omics framework on stem cell enriched and -depleted mouse intestinal organoids to obtain a holistic view of the molecular mechanisms that drive differential gene expression during adult intestinal stem cell differentiation. Our data revealed a global rewiring of the transcriptome and proteome between intestinal stem cells and enterocytes, with the majority of dynamic protein expression being transcription-driven. Integrating absolute mRNA and protein copy numbers revealed post-transcriptional regulation of gene expression. Probing the epigenetic landscape identified a large number of cell-type specific regulatory elements, which revealed Hnf4g as a major driver of enterocyte differentiation. In summary, by applying an integrative systems biology approach we uncovered multiple layers of gene expression regulation, which contribute to lineage specification and plasticity of the mouse small intestinal epithelium.

2018-06-25 | PXD009700 | Pride

Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape [rna-seq]

Project description:Gene expression data in 4 populations of intestinal epithelial cells defined by different levels of Sox9 expression.

2019-05-24 | GSE131244 | GEO

Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape [atac-seq]

Project description:Genome-wide chromatin accessbilility data in 4 populations of intestinal epithelial cells defined by different levels of Sox9 expression.

2019-05-25 | GSE131440 | GEO

Intestinal stem cell differentiation is associated with dynamic changes in the chromatin landscape [5hmc-seal-seq]

Project description:The global localization of 5-hydroxymethylcytosine (5hmc) were measured by 5hmc-seal-seq in four populations of intestinal epithelium defined by their levels of a GFP reporter transgene that is driven by the regulatory elements of the Sox9 gene.

2019-05-24 | GSE131245 | GEO

Reprogramming Landscape Highlighted by Dynamic Transcriptomes in Therapy-induced Neuroendocrine Differentiation

Project description:Reprogramming Landscape Highlighted by Dynamic Transcriptomes in Therapy-induced Neuroendocrine Differentiation

| PRJNA891317 | ENA

Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells

Project description:Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells

| PRJNA352947 | ENA

Integrative multi-omics analysis of intestinal organoid differentiation

Project description:Intestinal organoids accurately recapitulate epithelial homeostasis in vivo, thereby representing a powerful in vitro system to investigate lineage specification and cellular differentiation. Here, we applied a multi-omics framework on stem cell-enriched and stem cell-depleted mouse intestinal organoids to obtain a holistic view of the molecular mechanisms that drive differential gene expression during adult intestinal stem cell differentiation. Our data revealed a global rewiring of the transcriptome and proteome between intestinal stem cells and enterocytes, with the majority of dynamic protein expression being transcription-driven. Integrating absolute mRNA and protein copy numbers revealed post-transcriptional regulation of gene expression. Probing the epigenetic landscape identified a large number of cell-type-specific regulatory elements, which revealed Hnf4g as a major driver of enterocyte differentiation. In summary, by applying an integrative systems biology approach, we uncovered multiple layers of gene expression regulation, which contribute to lineage specification and plasticity of the mouse small intestinal epithelium.

2018-06-22 | GSE114113 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data